Research, Malaria Elimination

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

Duration
October 1st 2021 - October 1st 2024
Coordinator
Hernando A. del Portillo Obando
Funded by
“la Caixa” Foundation

Infectious diseases, many of them forgotten, kill 17 million people every year in the poorest regions on the planet. One such disease is malaria caused by the world’s most widely distributed malaria parasite, Plasmodium vivax.

One of the many unanswered questions is the origin of asymptomatic chronic infections with numerous epidemiological field studies supporting >90% of such infections. One hypothesis is that nanovesicles called exosomes, mediate cryptic infections in the human bone marrow and spleen, with clear implications for malaria elimination.

This project aims to develop a miniature model of human bone marrow and spleen (organ-on-a-chip technology) to investigate the parasite’s hiding places in the organism, uncover the role of the exosomes and eliminate malaria.

Total Funding

996,930.57 euro

Our Team

Coordinator

ISGlobal Team

Other projects

See Past Projects

MESA

The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.

RTS,S Vaccine Immunology Study

Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial

MiPMon

Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission

AlphaGal

Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite

TIPTOP

Transforming IPT for optimal pregnancy

NANOpheles

Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites

BOHEMIA

Broad One Health Endectocide-based Malaria Intervention in Africa

ASINTMAL

Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

GenMoz

P. falciparum genomic intelligence in Mozambique

ADAM

Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

ECO

Enhanced and equitable coverage of COVID-19 testing and treatment in Bolivia and Paraguay

Science4Pandemics

Citizens engagement digital platform for collective intelligence in pandemics