Publicador de contenidos

Investigación e Innovación Programas
Investigación

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Cadena de ADN
Foto: Canva
Duración
01/06/2023 - 01/06/2027
Coordinador
Amsterdam Institute for Global Health and Development (AIGHD)
Financiadores
EDCTP3

The 21st century is witnessing an increased incidence of epidemics (Zika, Dengue, Ebola, SARS), with the recent COVID-19 being the latest highlight. Following the outbreak of several infectious diseases in the last decade, the need to generate real-time pathogen genomic data for public health interventions has become more important than ever.

In the African context, infrastructure, human resource capacity, data analysis including bioinformatics, lack of linkage between clinical, epidemiological and pathogen genomic data and interaction between clinicians, researchers and decision makers are some of the major challenges.

Objectives

The EpiGen project aims to build capacity for integrated pathogen genomic surveillance for informed public health decision-making.

The overarching specific objectives include strengthening the collection and analysis of clinical and epidemiological data; enhancing the capacity and capability for pathogen genomic sequencing, including strengthening laboratory infrastructure, human resources, pathogen genomic data analysis and integration of metadata with genomic data; developing and implementing innovative digital diagnostic platforms; creating semi-real-time mobile phone applications for policy making; and promoting communities of practice and knowledge exchange by fostering African collaboration and networking in the field of pathogen genomic surveillance for infectious diseases.

The Consortium

The multidisciplinary consortium of the EpiGen project consists of several Ethiopian institutions involved in national public health programmes and EU partners (Netherlands, Spain and Germany).

Overall, the model approach proposed by EpiGen will strengthen Ethiopia's national efforts to reduce the threat of infectious diseases. The implementation of national genomics-informed surveillance for infectious diseases will play an important public health role in contributing to disease prevention and control programmes in Ethiopia and beyond.

Total Funding

5,500,000 € (EDCTP3)

Nuestro equipo

ISGlobal Staff Involved

Otros proyectos

Ver proyectos pasados

COMBACTE

Combatiendo la Resistencia Bacteriana en Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

MESA

La Alianza Científica para la Erradicación de la Malaria (MESA) tiene como objetivo avanzar en la ciencia de la erradicación de la malaria.

NHEPACHA

Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas

Estudio inmunológico de la vacuna RTS,S

Estudio de correlatos de protección frente a la malaria después de la vacunación con RTS,S/AS01E: Una evaluación inmunológica exhaustiva en el ensayo clínico de Fase III, doble ciego, aleatorizado, multicéntrico con un grupo control

Euroleish.net

Control of Leishmaniasis. From bench to bedside and community

GREPIMER

Grup de recerca en patología importada i malaties emergents i re-emergents

TESEO

Nuevos regímenes de quimioterapia y biomarcadores para la enfermedad de Chagas

ASINTMAL

Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

ADAM

Administración masiva y focal de fármacos antimaláricos para avanzar hacia la eliminación de la malaria en Mozambique: acelerando la implementación de programas y políticas

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

Science4Pandemics

Citizens engagement digital platform for collective intelligence in pandemics

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

MENA Migrant Health

Transforming data collection and surveillance to drive migrant health research, care and policy

SexMal

Social affairs and sex in P. falciparum: implications for malaria elimination

SMART

Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test

MalTransc

Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses

GenMoz

P. falciparum genomic intelligence in Mozambique

BOHEMIA

Broad One Health Endectocide-based Malaria Intervention in Africa

RESPONSE

Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum

VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

VaMonoS

Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria

CLIMSOCTRYPBOL

Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.