Environmental hazards account for a probably large, but not well characterised, proportion of the burden of disease. The exposome, described as "the totality of human environmental exposures from conception onwards", recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. The exposome’s main advantage over traditional ‘one-exposure-one-disease’ study approaches is that it provides an unprecedented conceptual framework for the study of multiple environmental hazards (urban, chemical, lifestyle, social) and their combined effects.
Promises of the Exposome
- Holistic → Complex system, multiple exposures, mixtures.
- Life-course → Temporal sequence.
- New tools/technology → Coverage and accuracy of exposures (omics, sensors, etc.).
- Internal exposome → Early biological responses.
- Untargeted discovery → Unknown exposures.
The characterisation of the exposome and its related health effects requires continuous innovation in the development of tools and methods, including for exposure assessment, integration of omics markers, data infrastructures, and complex data analysis. Interdisciplinary collaboration is key to this.
ISGlobal has established itself at the forefront of international exposome research through its coordination of, and partnership in, several large international exposome projects funded by the European Commission (see projects).
ISGlobal’s Exposome Research Hub brings together a cross-faculty network of researchers across the following programmes:
- Air Pollution and Urban Environment
- Climate and Health (AIRLAB)
- Childhood and Environment
- Non-communicable Diseases and Environment
This in order to promote excellence, innovation, and collaboration in exposome research, and to meet the training needs of researchers in this field.
Large Exposome Projects at ISGlobal
Lines of Research across ISGlobal Programmes
- Internal exposome, chemical exposures, endocrine disruptors.
- External exposome, urban environment (e.g. air pollution, noise, built environment including green spaces), GIS-based exposure characterization, and modelling and measurement of exposures.
- Working-life exposome, harmonisation of occupational exposure assessment throughout Europe (EuroJEM).
- Biological responses/internal exposome through omics technologies, epigenetics, transcriptomics, inflammatory proteins, allostatic load, accelerated ageing, gut microbiome, metabolomics.
- Cohort implementation and harmonization: mega-cohorts for occupational health, longitudinal mother-child cohorts, adult cohorts, mega-cohorts from administrative data.
- Exposure and health: mental health and neurodevelopment, cardio-metabolic health, obesity, respiratory health.
- Bioinformatics for multi-omics integration, federated data analysis (analyses when data are stored on federated databases or, more generally, in different repositories, e.g. Datashield).
- Advanced data modelling for exposure mixtures and causal inference.
- Characterization of the air from urban and rural environments: determination of physical properties of particles (from coarse to ultrafine particles), analysis of chemical (metals, non-metals, etc.) and biological (bacteria, fungi and viruses) composition. AIRLAB: core facility laboratory.
- Lea Maitre Assistant Research Professor
Hub Project Manager
- Rodney Ortiz Project Manager
- Maria Foraster Assistant Research Professor
- Sofya Pozdniakova Postdoctoral fellow
- Cathryn Cecelia Tonne Associate Research Professor
- Michelle Turner Associate Research Professor
- Martine Vrijheid Jefa del programa de Infancia y medio ambiente, Research Professor y Coordinadora de la Cohorte INMA-Sabadell
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
Early-life stressors and LifeCycle health
EXposome Powered tools for healthy living in urbAN SEttings
Otros proyectosVer proyectos pasados
Engaging Citizens in Science: Promoting the Viability of Participatory Sensing for Monitoring Air and Environmental Quality
Estudio Internacional de la Mente, Actividades y Entornos Urbanos en Barcelona
Aging Lungs in European Cohorts
Physical Activity as a Crucial Patient Reported Outcome in COPD
Social and environmental determinants of physical activity in patients with chronic obstructive pulmonary disease (COPD): a qualitative and quantitative epidemiological study
Impact Of Pollution on Asthma and Rhinitis
Las Voces de los Afectados por la Nefropatía Mesoamericana
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Pregnancy and Childhood Epigenetics
Science and Technology in childhood Obesity Policy
Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents
Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers
Developmental origins of child liver injury: the effect of early life environmental exposures
External and Internal Human Exposure in Urban EXposome
Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia
Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways
Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment
Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence
Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age
Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants
Light at Night Exposure and Sleep Quality
Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus
The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
Arctic Impact on Weather and Climate
Health Sector Engagement for the Copernicus Climate Change Services: Translating European Users Requirements