- Alfredo Mayor (ISGlobal)
- Bill and Melinda Gates Foundation
Mozambique is among the ten countries with the highest burden of malaria worldwide. At the same time, the National Malaria Control Program (NMCP) of Mozambique seeks to accelerate elimination in the south, where transmission is lowest. NMCP is currently working with partners to set up a high-resolution surveillance system that can drive decision-making across all transmission strata through strengthening of routine data quality, data use and data to action packages. However, decisions become more complex as control reveals heterogeneity and better tools are required for a strategic use of information to drive impact.
The overall aim of the GenMoz project is to build malaria genomic capacities in Mozambique in order to increase the actionable intelligence for making programmatic decisions on the optimal mix of control and elimination measures in Mozambique. The project proposes a participatory approach engaging all parts of the health system to promote a culture of genetic data use and increase the public health impact, while leveraging ongoing activities and existing capacity in Mozambique.
We will first develop analytical and interpretive genomic capacities at the Manhiça Health Research Center (CISM), an institution with extensive experience in malaria research and a pivotal role in contributing to the development of the Mozambican Ministry of Health's overall health policy. We will then integrate genomic intelligence in the NMCP’s strategic and operational activities through:
- Embedding genetic surveillance on ongoing and future routine control and elimination strategies (e.g. use of routine samples).
- The integration of genomic surveillance onto the Integrated Malaria Information Storage System (iMISS) for analysing, visualising and generating data for action (e.g. through genetic surveillance dashboards) at the appropriate granularity level.
The project will be conducted by the Manhiça Health Research Center (Mozambique) in close collaboration with ISGlobal, Malaria Consortium, the University of California-San Francisco and the Institute of Disease Modelling.
5 910 781 USD dollars
Centro de Investigação em Saúde de Manhiça (CISM)
- Francisco Saúte
- Pedro Aide
- Gloria Matambisso
- Meritxell Molinos
- Delfino Vubil
- Arsenio Nhacolo
National Malaria Control Program in Mozambique:
- Baltazar Candrinho
University of California San Francisco:
- Bryan Greenhouse
- Arantxa Roca
Institute of Disease Modelling
- Caitlin Bever
- Josh Proctor
Instituto de Biomedicina de Valencia (IBV-CSIC)
- Iñaki Comas
Otros proyectosVer proyectos pasados
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.
Estudio de correlatos de protección frente a la malaria después de la vacunación con RTS,S/AS01E: Una evaluación inmunológica exhaustiva en el ensayo clínico de Fase III, doble ciego, aleatorizado, multicéntrico con un grupo control
Alianza Mozambiqueña para la Eliminación de la Malaria
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
A path towards new diagnostic and prevention tools for severe infectious pathologies
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasite
Transforming IPT for optimal pregnancy
Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
Broad One Health Endectocide-based Malaria Intervention in Africa
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
Administración masiva y focal de fármacos antimaláricos para avanzar hacia la eliminación de la malaria en Mozambique: acelerando la implementación de programas y políticas
MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention