Environmental hazards account for a probably large, but not well characterised, proportion of the burden of disease. The exposome, described as "the totality of human environmental exposures from conception onwards", recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. The exposome’s main advantage over traditional ‘one-exposure-one-disease’ study approaches is that it provides an unprecedented conceptual framework for the study of multiple environmental hazards (urban, chemical, lifestyle, social) and their combined effects.
Promises of the Exposome
- Holistic → Complex system, multiple exposures, mixtures.
- Life-course → Temporal sequence.
- New tools/technology → Coverage and accuracy of exposures (omics, sensors, etc.).
- Internal exposome → Early biological responses.
- Untargeted discovery → Unknown exposures.
The characterisation of the exposome and its related health effects requires continuous innovation in the development of tools and methods, including for exposure assessment, integration of omics markers, data infrastructures, and complex data analysis. Interdisciplinary collaboration is key to this.
ISGlobal has established itself at the forefront of international exposome research through its coordination of, and partnership in, several large international exposome projects funded by the European Commission (see projects).
ISGlobal’s Exposome Research Hub brings together a cross-faculty network of researchers across the following programmes:
- Air Pollution and Urban Environment
- Climate and Health (AIRLAB)
- Childhood and Environment
- Non-communicable Diseases and Environment
This in order to promote excellence, innovation, and collaboration in exposome research, and to meet the training needs of researchers in this field.
Large Exposome Projects at ISGlobal
Lines of Research across ISGlobal Programmes
- Internal exposome, chemical exposures, endocrine disruptors.
- External exposome, urban environment (e.g. air pollution, noise, built environment including green spaces), GIS-based exposure characterization, and modelling and measurement of exposures.
- Working-life exposome, harmonisation of occupational exposure assessment throughout Europe (EuroJEM).
- Biological responses/internal exposome through omics technologies, epigenetics, transcriptomics, inflammatory proteins, allostatic load, accelerated ageing, gut microbiome, metabolomics.
- Cohort implementation and harmonization: mega-cohorts for occupational health, longitudinal mother-child cohorts, adult cohorts, mega-cohorts from administrative data.
- Exposure and health: mental health and neurodevelopment, cardio-metabolic health, obesity, respiratory health.
- Bioinformatics for multi-omics integration, federated data analysis (analyses when data are stored on federated databases or, more generally, in different repositories, e.g. Datashield).
- Advanced data modelling for exposure mixtures and causal inference.
- Characterization of the air from urban and rural environments: determination of physical properties of particles (from coarse to ultrafine particles), analysis of chemical (metals, non-metals, etc.) and biological (bacteria, fungi and viruses) composition. AIRLAB: core facility laboratory.
- Lea Maitre Assistant Research Professor
Hub Project Manager
- Ariadna Moreno Project Manager
- Maria Foraster Assistant Research Professor
- Sofya Pozdniakova Postdoctoral Researcher
- Cathryn Cecelia Tonne
- Michelle Turner Associate Research Professor
- Martine Vrijheid Head of the Childhood and Environment Programme, Research Professor and Coordinator of INMA-Sabadell Cohort
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
Exposome Project for Health and Occupational Research
Early-life stressors and LifeCycle health
EXposome Powered tools for healthy living in urbAN SEttings
Other projectsSee Past Projects
Engaging Citizens in Science: Promoting the Viability of Participatory Sensing for Monitoring Air and Environmental Quality
BiblioLab Ciencia - Ciudad Saludable
Planificación urbana, medio ambiente y salud
The international Mind, Activities and urban Places in Barcelona study (iMAP Barcelona study): Building the evidence base on the relationships between environment, active living and cognitive health
Calor, trabajo y salud: caracterización de la exposición, marcadores de salud y efectividad de intervenciones
Project Code: PI20/00608
EXPLICA - Uso del EXPosoma para eLucIdar los factores promotores del riesgo CArdiovascular en entornos urbanos
Project Code: PI21/00930
ALEC (Aging Lungs in European Cohorts)
Ageing Lungs in European Cohorts
Physical Activity as a Crucial Patient Reported Outcome in COPD
Global Assessment of Trihalomethanes in Drinking Water
Impact Of Pollution on Asthma and Rhinitis
Las Voces de los Afectados por la Nefropatía Mesoamericana
Metabolomic Analysis as a Window into the Etiology of Mesoamerican Nephropathy
Alimentación S2: por una dieta saludable y sostenible
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
The Urban Burden of Disease Estimation for POLICY Making
Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Pregnancy and Childhood Epigenetics
European Human Biomonitoring Initiative
Prenatal and Postnatal Windows Vulnerability in the Risk of Neurodevelopmental Delay Associated with Particulate Air Pollution
STOP - Childhood Obesity
Science and Technology in childhood Obesity Policy
The Lungfit Project
Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents
Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers
Developmental origins of child liver injury: the effect of early life environmental exposures
External and Internal Human Exposure in Urban EXposome
Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia
Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways
The APBO Project
Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment
Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence
Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age
Air Pollution, Placental ‘Small Non-Coding RNAs’ and Brain Development
Contaminació atmosfèrica durant l’embaràs i primers anys de vida, miRNAs i salut infantil
The Role of Stress and Stress Reactivity in Mediating Impacts of Air Pollutants on the Brain and Lungs
Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants
Light at Night Exposure and Sleep Quality
Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus
El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)
Project Code: PI21/01269
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
Pan-European Urban Climate Service (PUCS)
Arctic Impact on Weather and Climate
Health Sector Engagement for the Copernicus Climate Change Services: Translating European Users Requirements
How Urban Planning Can Influence Child’s Neurodevelopment?
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Early-life Exposure to the So-called “forever” Chemicals, the PFAS, and Cardiometabolic Health of Children
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