ALEC

Aging Lungs in European Cohorts

Duración
01/05/2015-30/04/2019
Coordinador
Judith Garcia Aymerich
Financiadores
EU-H2020-Health

Chronic obstructive pulmonary disease (COPD) is a major cause of disease, disability and death in European adults and lung function is a critical objective marker of good lung health, strongly associated with other major chronic diseases (for example, cardiovascular disease) and is a major independent determinant of overall health status.

This study will improve our understanding of risk factors for low lung function, respiratory disability and the development of COPD, by using information held within existing cohort studies. Even though COPD has long been viewed as a predominantly smoking-related disease, there is increasing awareness that lifestyle and environment contribute to disease even from very early in life, including before birth.

To deliver this work stream, ALEC has 7 workpackages focused on:

  • Study management
  • Dissemination
  • Risk factor identification: pre-conception and transgenerational
  • Risk factor identification: childhood
  • Risk factor identification: adulthood
  • Generation of new data from ECRHS and SAPALDIA on change in DNA methylation (DNAm)
  • Integration and Translation of findings into a predictive risk score for COPD

We are leading the workpackage focused on adulthood, with the following objectives and methods:

  1. To identify and validate the causal role of plausible and novel risk factors for lung function decline within existing population based cohorts, taking into account changes in exposure over time.
  2. To strengthen causal inference of the role of these risk factors by integrating biomarker and genetic information, using structural equation modelling as well as Mendelian randomisation.
  3. To describe the association of lung function decline with the development of respiratory disability within the population based cohorts.
  4. To integrate information with other work packages:
    • assess the role of transgenerational, preconception and early life risk factors identified on lung function decline,
    • integrate findings into risk models as they arise, c) suggest pathways for mechanistic investigation,
    • identify risk factors and appropriate exposure metrics for integration in predictive risk score.
  5. To integrate and summarise findings into a conceptual model for lung function decline in adults.

 

Total Funding:

496,026 €

Nuestro equipo

Investigador principal (IP)

  • Judith Garcia
    Judith Garcia Jefa del programa de Enfermedades No Transmisibles y Medio Ambiente

Equipo ISGlobal

Ver más

Otros proyectos

Ver proyectos pasados

MCC-Spain

Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España

PROactive

Physical Activity as a Crucial Patient Reported Outcome in COPD

QUALI-VERD

Social and environmental determinants of physical activity in patients with chronic obstructive pulmonary disease (COPD): a qualitative and quantitative epidemiological study

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

POLLAR

Impact Of Pollution on Asthma and Rhinitis

CORSAIR

Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors

VEIS

Valorización del Archivo Europeo del Genomas y Fenomas (EGA) para la Industria y la Sociedad

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

COVICAT

Cohorte Covid-19 en Cataluña

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

AiguaBCN

Exposure to emerging contaminants in drinking water in Barcelona potentially liked to chronic diseases and wellbeing

Fotovoz

Las Voces de los Afectados por la Nefropatía Mesoamericana

CALMA

Co-created educational programme for dyspnea-bearing patients and their caregivers

Cancer-Watch

Risk of colorectal and breast cancer with widespread drinking water chemical contaminants

CONTENT

Cohorte de COVID-19 en España: dinámica social, salud mental y desigualdades

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia