- 01/07/2021 - 30/06/2025
- Iñaki Comas Espadas
- Funded by
- European Research Council (ERC)
The aim of the TB- RECONNECT is to shed light burning questions about the nature of tuberculosis (TB) transmission and the host and pathogen biology behind it, by synergizing three recent TB research developments:
- 1) The use of host blood transcriptomics to discriminate between infection status within the latent pool of individuals.
- 2) Quantification of transmission at a resolution not previously available, using pathogen genome sequencing.
- 3) The application of phylogenetic and epidemiological models to identify when transmission has happened.
Combining these three key developments with TB cohorts from multiple settings, and available tools from bacterial population genetics, high-throughput functional genomics and infection biology, we will be in a key position to reconnect transmission to TB control and inform major shifts in global and local control strategies.
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Application to medical devices
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africa
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo
Pilot Study to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission
Cendea de Cizur
Conèixer la propagació. Entendre la protecció
A breakthrough device for the rapid detection of antimicrobial resistance
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Hepatitis B Virus COMmunity Screening and Vaccination in Africans
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
Close the Gap, Increase Access, Provide Adequate Therapy
Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19
Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring