Environmental hazards account for a probably large, but not well characterised, proportion of the burden of disease. The exposome, described as "the totality of human environmental exposures from conception onwards", recognizes that individuals are exposed simultaneously to a multitude of different environmental factors and takes a holistic approach to the discovery of etiological factors for disease. The exposome’s main advantage over traditional ‘one-exposure-one-disease’ study approaches is that it provides an unprecedented conceptual framework for the study of multiple environmental hazards (urban, chemical, lifestyle, social) and their combined effects.
Promises of the Exposome
- Holistic → Complex system, multiple exposures, mixtures.
- Life-course → Temporal sequence.
- New tools/technology → Coverage and accuracy of exposures (omics, sensors, etc.).
- Internal exposome → Early biological responses.
- Untargeted discovery → Unknown exposures.
The characterisation of the exposome and its related health effects requires continuous innovation in the development of tools and methods, including for exposure assessment, integration of omics markers, data infrastructures, and complex data analysis. Interdisciplinary collaboration is key to this.
ISGlobal has established itself at the forefront of international exposome research through its coordination of, and partnership in, several large international exposome projects funded by the European Commission (see projects).
ISGlobal’s Exposome Research Hub brings together a cross-faculty network of researchers across the following programmes:
- Air Pollution and Urban Environment
- Climate and Health (AIRLAB)
- Childhood and Environment
- Non-communicable Diseases and Environment
This in order to promote excellence, innovation, and collaboration in exposome research, and to meet the training needs of researchers in this field.
Large Exposome Projects at ISGlobal
Lines of Research across ISGlobal Programmes
- Internal exposome, chemical exposures, endocrine disruptors.
- External exposome, urban environment (e.g. air pollution, noise, built environment including green spaces), GIS-based exposure characterization, and modelling and measurement of exposures.
- Working-life exposome, harmonisation of occupational exposure assessment throughout Europe (EuroJEM).
- Biological responses/internal exposome through omics technologies, epigenetics, transcriptomics, inflammatory proteins, allostatic load, accelerated ageing, gut microbiome, metabolomics.
- Cohort implementation and harmonization: mega-cohorts for occupational health, longitudinal mother-child cohorts, adult cohorts, mega-cohorts from administrative data.
- Exposure and health: mental health and neurodevelopment, cardio-metabolic health, obesity, respiratory health.
- Bioinformatics for multi-omics integration, federated data analysis (analyses when data are stored on federated databases or, more generally, in different repositories, e.g. Datashield).
- Advanced data modelling for exposure mixtures and causal inference.
- Characterization of the air from urban and rural environments: determination of physical properties of particles (from coarse to ultrafine particles), analysis of chemical (metals, non-metals, etc.) and biological (bacteria, fungi and viruses) composition. AIRLAB: core facility laboratory.
- Lea Maitre Assistant Research Professor
Hub Project Manager
- Ariadna Moreno Project Manager
Novel tools for integrating early-life environmental exposures and child health across Europe
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
Early-life stressors and LifeCycle health
EXposome Powered tools for healthy living in urbAN SEttings
Other projectsSee Past Projects
Exposome Project for Health and Occupational Research
Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility
Calor, trabajo y salud: caracterización de la exposición, marcadores de salud y efectividad de intervenciones
Project Code: PI20/00608
Project Code: PI20/01116
EXPLICA - Uso del EXPosoma para eLucIdar los factores promotores del riesgo CArdiovascular en entornos urbanos
Project Code: PI21/00930
Population based multicasecontrol study on common tumours in Spain
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Pregnancy and Childhood Epigenetics
A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health
An integrative strategy of testing systems for identification of EDs related to metabolic disorders
Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics
Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development
El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)
Project Code: PI21/01269
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
ALTER - Contaminación del aire, microbiota intestinal y neurodesarrollo en los primeros 24 meses de vida
Project Code: PI21/01278
¿Es mejor consumir el agua de grifo si queremos reducir la exposición a nano/micropláticos?
Urban and social environment and childhood obesity – a natural moving2health experiment
Urban planning, environment and health
Characterization of Oral NMP Exposure
In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform
An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
Exposición prenatal a sustancias poli y perfluoradas en agua de consumo y neurodesarrollo en el inicio de la vida
Project Code: PI20/00829
Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease
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