LIFECYCLE
Early-life stressors and LifeCycle health
- Duración
- 2017-2021
- Coordinador
- Vincent Jaddoe (Erasmus MC-University Medical Center de Rotterdam)
- Financiadores
- European Comission - Horizon 2020
- Página web
- http://www.lifecycle-project.eu
Early life is an important window of opportunity to improve health across the full lifecycle. European pregnancy and child cohort studies together offer a unique opportunity to identify a wide range of early life stressors linked with individual biological, developmental and health trajectory variations, and to the onset and evolution of noncommunicable diseases.
LifeCycle will establish the EU CHILD Cohort Network, which brings together existing, successful pregnancy and child cohorts and biobanks, by developing a governance structure taking account of national and European ethical, legal and societal implications, a shared data-management platform and data-harmonization strategies.
The project will enrich this EU CHILD Cohort Network by generating new integrated data on early life stressors related to socio-economic, migration, urban environment and life-style determinants, and will capitalize on these data by performing hypothesis-driven research on early life stressors influencing cardio-metabolic, respiratory and mental health trajectories during the full lifecycle, and the underlying epigenetic mechanisms. LifeCycle will translate these results into recommendations for targeted strategies and personalized prediction models to improve health trajectories for current and future Europeans generations by optimizing their earliest phase of life.
To strengthen this long-term collaboration, LifeCycle will organize yearly international meetings open to pregnancy and child cohort researchers, introduce a Fellowship Training Programme for exchange of junior researchers between European pregnancy or child cohorts, and develop e-learning modules for researchers performing life-course health studies.
Ultimately, the project will lead to a unique sustainable EU CHILD Cohort Network, and provide recommendations for targeted prevention strategies by identification of novel markers of early life stressors related to health trajectories throughout the lifecycle.
This ambitious project combines data on over 250,000 children and their parents from Europe and Australia to provide robust scientific evidence on this important topic. Research findings will be translated into new prevention and intervention policies focused on the earliest phase of life, giving next generations the best possible start.
Partners
- Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands (Coordinator)
- ISGlobal, Barcelona, Spain
- University of Turin, Italy
- University of Southampton, United Kingdom
- University of Bristol, United Kingdom
- University of Copenhagen, Denmark
- Bradford Teaching Hospitals NHS Foundation Trust, United Kingdom
- University Medical Center Groningen, The Netherlands
- University of Crete, Greece
- Norwegian Institute of Public Health, Oslo, Norway
- French National Institute of Health and Medical Research (INSERM), Villejuif, France
- University of Oulu, Finland
- Samfundet Folkhälsan, Helsinki, Finland
- Ludwig Maximilians University of Munich, Germany
- VU University Amsterdam , The Netherlands
- Concentris Research Management GmbH
- University of Western Australia, Perth, Australia
Total funding
10,4 milions.
Nuestro equipo
Principal Investigators (PI)
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Martine Vrijheid Jefa del programa de Infancia y medio ambiente, Research Professor y Coordinadora de la Cohorte INMA-Sabadell
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Jordi Sunyer Research Professor
ISGlobal Team
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Xavier Basagaña Associate Research Professor
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Mariona Bustamante Staff Scientist
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Lourdes Cirugeda Data Manager INMA
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Jordi Júlvez Associated Researcher
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Mònica López Investigadora posdoctoral
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Mark J Nieuwenhuijsen Research Professor, Director de la Iniciativa de Planificación Urbana, Medio Ambiente y Salud, y jefe del programa de Contaminación Atmosférica y Entorno Urbano
Otros proyectos
Ver proyectos pasadosEGG/EAGLE
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
PACE
Pregnancy and Childhood Epigenetics
European Human Biomonitoring Initiative
HBM4EU
APACHE
Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe
Ventanas de vulnerabilidad pre-natal y post-natal en el riesgo de retraso en el neurodesarrollo asociado a la contaminación particulada del aire
STOP - Childhood Obesity
Science and Technology in childhood Obesity Policy
ATHLETE
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
MOOD-COVID
Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic
EUCAN-Connect
A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health
OBERON
An integrative strategy of testing systems for identification of EDs related to metabolic disorders
The Lungfit Project
Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents
ExPEC-TEEN
Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers
AURORA 2021
Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics
HELIX-NAFLD
Developmental origins of child liver injury: the effect of early life environmental exposures
H2020-New URBAN_X
External and Internal Human Exposure in Urban EXposome
UrbaMet
Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia
NutriPROGRAM
Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways
ONES
Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility
AIR-NB
Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development
FRONTIER
Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status
The APBO Project
Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment
INMA-Ado-Sueño
Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence
ANSES HyPAXE
Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age
Air Pollution, Placental ‘Small Non-Coding RNAs’ and Brain Development
Contaminació atmosfèrica durant l’embaràs i primers anys de vida, miRNAs i salut infantil
The Role of Stress and Stress Reactivity in Mediating Impacts of Air Pollutants on the Brain and Lungs
EXPO-ENFANTS
Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants
Lilli
Light at Night Exposure and Sleep Quality
EMBRYORAD
Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus
El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)
Project Code: PI21/01269
NutinBrain
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
ALTER - Contaminación del aire, microbiota intestinal y neurodesarrollo en los primeros 24 meses de vida
Project Code: PI21/01278
UrbanKids
Urban and social environment and childhood obesity – a natural moving2health experiment
5G expOsure, causaL effects, and rIsk perception through citizen engAgemenT
GOLIAT
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
Base genética materna y fetal de la función placentaria
Project Code: PI20/01116