Asset Publisher

Research, Maternal, Child and Reproductive Health


Transforming IPT for optimal pregnancy

Clara Menéndez
Funded by

In sub-Saharan Africa (SSA), over 30 million pregnant women are annually exposed to infection from malaria. Of these, an estimated 10,000 pregnant women and up to 200,000 newborns die from malaria in pregnancy (MiP), primarily due to the infection from Plasmodium falciparum bites. Furthermore, recent data indicate that up to 20% of stillbirths in SSA are attributable to MiP. In the broader framework of the 2030 agenda, the TIPTOP project is well aligned with the overall SDG3 health targets of accelerating maternal and newborn mortality reduction in the Sub Saharan region and reflects well how different stakeholders have a role and responsibility in helping to achieve these ambitious goals: from sub Saharan African countries to donors, international development and research partners.

IThis 5-year project, funded by UNITAID and implemented by Jhpiego (coordinator) and ISGlobal (research partner) in collaboration with the World Health Organization (WHO) and the Medicines for Malaria Venture (MMV), aims to increase intermittent preventive treatment in pregnancy (IPTp) for malaria with sulfadoxine-pyrimethamine (SP)—in addition to the use of insecticide-treated bed nets (ITNs) and effective case management IPTp coverage— and expand antenatal care attendance primarily through Community Health Workers in four Sub Saharan African countries: DRC, Mozambique, Madagascar and Nigeria. A learning-driven approach will be employed throughout the project to guide expansion in a two-phase process and generate sufficient evidence to inform WHO policy recommendations and future actions in each country, in an effort to expand the intervention over the long-term.

In an initial phase 10,000 pregnant women per country are expected to be reached (2 years). Then in the so-called expansion phase (3 years) 30,000 pregnant women per country will be enrolled. This project plans to engage community health workers to increase IPTp delivery and demand, catalyzing and further encouraging scale-up of IPTp in Africa. Additionally, it will expand antenatal care attendance in these four African countries.

ISGlobal is the lead evaluation and research organization and is responsible for implementing a set of studies to generate evidence for global guidance on community IPTp-SP. Specifically, ISGlobal will be responsible for designing and implementing the project’s evaluation plan, as well as designing, analyzing and reporting the operational research studies to assess the cost and acceptability of the intervention and its impact.

Total funding:

  • Total Project Funding: $50M
  • Total ISGlobal Funding: $10.4 M

More Information:


Our Team


  • Clara Menéndez
    Clara Menéndez Research Professor, Director of the Maternal, Child and Reproductive Health Initiative and Programme

ISGlobal team

See More

Other projects

See Past Projects


Improving Care through Azithromycin Research for Infants in Africa


Sharing knowledge and catalyzing research towards a malaria-free world


New Tools for the Diagnosis and Evaluation of Chagas Disease

RTS,S Vaccine Immunology Study

Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial

Control of Leishmaniasis. From bench to bedside and community


Grup de recerca en patología importada i malaties emergents i re-emergents


New chemotherapy regimens and biomarkers for Chagas Disease


Broad One Health Endectocide-based Malaria Intervention in Africa


Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults


Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation


MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention


Citizens engagement digital platform for collective intelligence in pandemics


Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

MENA Migrant Health

Transforming data collection and surveillance to drive migrant health research, care and policy


Social affairs and sex in P. falciparum: implications for malaria elimination


Building Scalable Pathogen Genomic Epidemiology in Ethiopia


Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test


Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses


P. falciparum genomic intelligence in Mozambique


Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death


Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women


Identification of Prematurity and Pre-Eclampsia as Causes of Mortality


Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations


Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone


Respiratory syncytial virus (RSV) in African pregnant women and children


Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique