Research

Non-communicable Diseases and Environment

(Judith Garcia-Aymerich)

Non-communicable diseases (NCDs), including heart disease, stroke, cancer, diabetes and chronic lung diseases, collectively account for more than 70% of all deaths worldwide, 85% of which occur in low- and middle-income countries.

NCDs are becoming extremely prevalent due to a combination of increased life expectancy and increased prevalence of major known risk factors such as smoking, air pollution, obesogenic diet, physical inactivity and occupational exposures, as well as contextual changes in socio-economic and environmental factors such as poverty, urban structure and climate change.

ISGlobal's NCDs and Environment Programme aims to study the causes and mechanisms of NCD development and progression, spanning the entire life course, from the prenatal period to late adulthood in high-income and low- and middle-income countries. We focus on the following determinants: environmental (air pollution, built and natural environment, light exposure, chemical water pollution, climate and global environmental crisis), occupational (occupational exposures, work shifts, occupational heat stress), lifestyle (sleep, physical activity, diet) and genetic and molecular (genomics, epigenomics, molecular biomarkers); and on the following diseases: cancers, respiratory, allergic, cardiometabolic (diabetes, obesity) and renal diseases, and neurological and mental health disorders, as well as multimorbidity and the interaction of NCDs with infections (COVID-19).

Our ultimate goal is to use the results of our research to prevent the onset and delay the progression of NCDs, in relation to the UN Sustainable Development Goals.

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