- Duration
- 01/05/2017-30/04/2022
- Coordinator
- Clara Menéndez
- Funded by
- UNITAID
- Website
- https://www.tiptopmalaria.org
In sub-Saharan Africa (SSA), over 30 million pregnant women are annually exposed to infection from malaria. Of these, an estimated 10,000 pregnant women and up to 200,000 newborns die from malaria in pregnancy (MiP), primarily due to the infection from Plasmodium falciparum bites. Furthermore, recent data indicate that up to 20% of stillbirths in SSA are attributable to MiP. In the broader framework of the 2030 agenda, the TIPTOP project is well aligned with the overall SDG3 health targets of accelerating maternal and newborn mortality reduction in the Sub Saharan region and reflects well how different stakeholders have a role and responsibility in helping to achieve these ambitious goals: from sub Saharan African countries to donors, international development and research partners.
IThis 5-year project, funded by UNITAID and implemented by Jhpiego (coordinator) and ISGlobal (research partner) in collaboration with the World Health Organization (WHO) and the Medicines for Malaria Venture (MMV), aims to increase intermittent preventive treatment in pregnancy (IPTp) for malaria with sulfadoxine-pyrimethamine (SP)—in addition to the use of insecticide-treated bed nets (ITNs) and effective case management IPTp coverage— and expand antenatal care attendance primarily through Community Health Workers in four Sub Saharan African countries: DRC, Mozambique, Madagascar and Nigeria. A learning-driven approach will be employed throughout the project to guide expansion in a two-phase process and generate sufficient evidence to inform WHO policy recommendations and future actions in each country, in an effort to expand the intervention over the long-term.
In an initial phase 10,000 pregnant women per country are expected to be reached (2 years). Then in the so-called expansion phase (3 years) 30,000 pregnant women per country will be enrolled. This project plans to engage community health workers to increase IPTp delivery and demand, catalyzing and further encouraging scale-up of IPTp in Africa. Additionally, it will expand antenatal care attendance in these four African countries.
ISGlobal is the lead evaluation and research organization and is responsible for implementing a set of studies to generate evidence for global guidance on community IPTp-SP. Specifically, ISGlobal will be responsible for designing and implementing the project’s evaluation plan, as well as designing, analyzing and reporting the operational research studies to assess the cost and acceptability of the intervention and its impact.
Total funding:
- Total Project Funding: $50M
- Total ISGlobal Funding: $10.4 M
More Information:
- Landmark Agreement Signed to Prevent Malaria in Pregnancy (ISGlobal)
- Landmark agreement signed to prevent malaria in pregnancy and reduce life-threatening complications in sub-Saharan Africa (UNITAID)
- Malaria in Pregnancy: Intermittent Preventive Treatment (ISGlobal)
Our Team
PI
-
Clara Menéndez Research Professor, Director of the Maternal, Child and Reproductive Health Initiative and Programme
ISGlobal team
-
Franco Massimo Giovanni Pagnoni Technical Cooperation Coordinator
-
Mireia Llach Medical Research Fellow
-
Maria del Pilar Fontserè Serra
-
Susana Méndez Bartolomé
-
Montse Pi Project Assistant
-
Maximo Ramirez Robles
Other projects
See Past ProjectsICARIA
Improving Care through Azithromycin Research for Infants in Africa
MESA
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.
RTS,S Vaccine Immunology Study
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial
Mozambican Alliance Towards Elimination of Malaria (MALTEM)
Mozambican Alliance Towards Elimination of Malaria
MiPMon
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
Severe malaria and microRNAs
A path towards new diagnostic and prevention tools for severe infectious pathologies
AlphaGal
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Epigenetic variation in malaria parasites II
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of P. vivax
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasite
NANOpheles
Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
BOHEMIA
Broad One Health Endectocide-based Malaria Intervention in Africa
ASINTMAL
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
GenMoz
P. falciparum genomic intelligence in Mozambique
ADAM
Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation
MULTIPLY
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ECO
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Science4Pandemics
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HIDDENVIVAX
Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria
CaDMIA-plus
Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death
METRO
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
MAMAH
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Infección por virus Zika en mujeres embarazadas que han viajado a zonas afectadas y evaluación de impacto en salud infantil
MIBio
Identification of Prematurity and Pre-Eclampsia as Causes of Mortality
STREESCO
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MA-CoV
Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations
IPERVAC-SL
Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone
RESPIRE
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VITAL
Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance