Research Programmes
Urban Planning, Environment and Health

APACHE

Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe

Duration
2017-2020
Coordinator
Mònica Guxens (ISGlobal)
Funded by
Health Effects Institute (HEI)

The objective of the APACHE study is to evaluate whether prenatal air pollution exposure is associated with the development of autism spectrum disorders and whether prenatal and postnatal air pollution exposure is associated with changes in brain structure and function in children. In both cases, the study will also evaluate different windows of exposure to establish when mothers and children are most vulnerable to the effects of air pollution.

One of the hypotheses to be evaluated in this study is that exposure to air pollution during pregnancy may be related to an increased risk of autism spectrum disorders, but not with an increased risk of autistic traits (subclinical deficits that do not meet the formal criteria for the diagnosis of autism spectrum disorder). This hypothesis is based on the findings of previous studies.

Our Team

Principal Investigator (PI)

ISGlobal Team

Other projects

See Past Projects

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

MOOD-COVID

Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

The Lungfit Project

Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

HELIX-NAFLD

Developmental origins of child liver injury: the effect of early life environmental exposures

UrbaMet

Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia

NutriPROGRAM

Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

ELHNA

Exposures to light pollution and heat, and neurodevelopment in adolescents

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

FRONTIER

Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status

The APBO Project

Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment

INMA-Ado-Sueño

Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

EXPO-ENFANTS

Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants

Lily

Light at Night Exposure and Sleep Quality

EMBRYORAD

Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus

IGRO

The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

ALTER

Air Pollution, Gut Microbiota and Neurodevelopment in the First 24 Months of Life

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment