- 01/10/2020 - 01/10/2024
- Alberto García-Basteiro
- Funded by
STool4TB is a project that aims to validate an innovative stool homogenization and DNA isolation method that yields a highly sensitive and specific Mtb qPCR-based diagnostic. STool4TB will evaluate this platform in the high TB and HIV burden settings of Mozambique, Eswatini and Uganda, under the hypothesis that it will narrow the large TB case detection gap by improving TB confirmation rates in children and PLHIV, while proving feasible and acceptable.
Preliminary data suggest that this platform adds value to existing sputum based diagnostics and increases rates of bacteriological confirmation. Given the lack of available tools to effectively monitor TB treatment, STool4TB will also evaluate the usefulness of this quantitative stool-based qPCR as a TB treatment monitoring tool for children and PLHIV.
This platform has the potential to be adapted to a POC diagnostic and thus easily implemented in resource-constrained basic health care centres. This proposal represents an opportunity to assess the feasibility, usability and acceptability of stool collection from both the patient and the health system perspective. STool4TB will create a biobank of comparative specimens provided by pediatric and HIV-positive TB patients (as well as TB-free individuals). The biobank will facilitate future evaluation of novel assays for pediatric TB diagnosis or drug resistance detection.
Finally, we aim to create a TB diagnostic network among African high TB burden countries with the capacity to conduct clinical studies of novel diagnostics and new drugs with a focus on children and PLHIV. This will be achieved by strengthening collaboration and sustaining capacity building activities among participating African institutions.
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting
Application to medical devices
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Integrating and decentralizing diabetes and hypertension services in Africa
Improving Care through Azithromycin Research for Infants in Africa
Predicting the Future: Incipient Tuberculosis
Cendea de Cizur
Conèixer la propagació. Entendre la protecció
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring
Planificación urbana, medio ambiente y salud | Clima y salud | Resistencias Antimicrobianas
ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)
Digital Twins Enabled Indoor Air Quality Management for Healthy Living
Estudio de la propagación de bacterias y genes de resistencia a los antibióticos en el ciclo integral del agua, en el área metropolitana de Barcelona
Propagación de la resistencia en aguas
Project Code: DTS21/00004
Más allá de la supresión vírica del VIH: un cuarto noventa para mejorar la salud de personas viviendo con el VIH en España
Project Code: PI20/01654
Viral Hepatitis COMmunity Screening, Vaccination, and Care
Community knowledge generation through scientific culture, urban ecology and art
Building Scalable Pathogen Genomic Epidemiology in Ethiopia