Although mortality from infectious disease has declined globally, viral and bacterial infections still have a disproportionate impact on the world's poorest populations, particularly children: pneumonia and diarrhoea are leading causes of infant death in low-income countries. Moreover, hundreds of millions of patients acquire infections in hospitals, particularly in developed countries. A large percentage of these infections are caused by multiresistant bacteria and the prevalence of these pathogens has risen alarmingly due to the misuse and abuse of antibiotics in health care and agriculture. Since multiresistant bacteria are found in all regions of the world and spread easily, they are deemed to be one of the most serious threats to global health.
In ISGlobal, we use our experience in this area to improve the diagnosis and treatment of infectious diseases, to improve our understanding of the causes of antibiotic resistance, and to find novel ways of combating resistant pathogens.
Main Lines of Research
- Design of new rapid diagnostic tools for infectious diseases
- Molecular basis of antimicrobial resistance
- Relationship between virulence and antimicrobial resistance
- Discovery and assessment of new antibacterial drugs
- Surveillance, phylogeny and clinical impact of influenza viruses and emerging viruses
- Search for diagnostic and prognostic biomarkers of viral and bacterial infections
- Pathogenesis and antimicrobial resistance of microorganisms that cause neonatal sepsis
- Epidemiology and clinical presentation of viral and bacterial infections
- Treatment of yaws in Papua New Guinea
Application to medical deviceshttp://www.nomorfilm.eu
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Emergencia de variantes de citomegalovirus portadoras de mutaciones asociadas a resistencia en trasplantados de órgano sólido
Resistencia a los antivirales del citomegalovirus en el trasplante
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Contributing to the road map of maternal immunization: Determining the burden of Bordetella pertussis, respiratory syncytial virus (RSV) and Influenza virus in pregnant women and their infants in Mozambique
Surveillance of Zika virus infection in pregnant women travelling from affected areas
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Optimisation and validation of a rapid, simple test for detecting bacteria resistant to beta-lactam antibiotics
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
New approaches for designing antibacterial compounds against multiresistant gram-negative bacteria
Development of New Metalloantibiotics Against Pathogens Associated to Chronic Infections in Cystic Fibrosis Patients
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique