- 04/10/2017 - 31/12/2018
- Joaquim Gascon
- Funded by
Phase 2 Randomized, Multicenter, Double-blinded Safety and Efficacy Study
The general objective of this clinical trial is to determine the efficacy and safety of alternative dosing regimens of FEXI in reducing and clearing T. cruzi parasitemia in adult individuals with the chronic indeterminate Chagas Disease, in comparison to historical placebo control.
This is a double-blind, randomized, prospective, comparative, pharmacokineticpharmacodynamic, and proof-of-concept trial design, with three-parallel groups and historical placebo control. The trial will be conducted in 5 different sites in Spain. The trial will be sufficiently powered to compare the efficacy and safety of each of the dosing regimens of FEXI with historical placebo control. Efficacy and safety will be monitored by an external independent Data Monitoring Committee (DMC) on an ongoing basis. The committee is to include cardiac and liver safety experts, as well as Chagas Disease clinical expertise.
The total duration of patient trial participation will be approximately 14 months.
- Joaquim Gascon Research Professor, Director of the Chagas Initiative, head of the Chagas, Parasitic and Imported Diseases programme
- Maria Jesús Pinazo Assistant Research Professor
- Carme Subirà Biosca
- Alba Abras Postdoctoral Fellow
- Julio Alonso Assistant Research Professor
- Irene Losada Research Assistant
- Glady Carranza Rivera
- Monica Solanes Desk Manager
Other projectsSee Past Projects
New Tools for the Diagnosis and Evaluation of Chagas Disease
Control of Leishmaniasis. From bench to bedside and community
Grup de recerca en patología importada i malaties emergents i re-emergents
Investigación aplicada al diagnóstico y tratamiento de los virus Zika, Dengue y Chikunguña
Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.
Model and Tool for designing strategies to scale up Chagas Disease care
Towards the interruption of transmission of soil-transmitted helminths
New chemotherapy regimens and biomarkers for Chagas Disease
Improving health data collection under the healthcare programme for migrant population in Nador, Morocco
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.