Publicador de continguts

Recerca

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

RECONNECT project
Durada
01/07/2021 - 30/06/2025
Coordinador
Iñaki Comas Espadas
Finançadors
European Research Council (ERC)

The aim of the TB- RECONNECT is to shed light burning questions about the nature of tuberculosis (TB) transmission and the host and pathogen biology behind it, by synergizing three recent TB research developments:

  • 1) The use of host blood transcriptomics to discriminate between infection status within the latent pool of individuals.
  • 2) Quantification of transmission at a resolution not previously available, using pathogen genome sequencing.
  • 3) The application of phylogenetic and epidemiological models to identify when transmission has happened.

Combining these three key developments with TB cohorts from multiple settings, and available tools from bacterial population genetics, high-throughput functional genomics and infection biology, we will be in a key position to reconnect transmission to TB control and inform major shifts in global and local control strategies.

Total Funding

530,000 €

Our Team

ISGlobal Team

  • Patricia Comella
    Patricia Comella Tècnica de recerca
  • Alberto García Basteiro
    Alberto García Basteiro
  • Belén Saavedra Cervera
    Belén Saavedra Cervera

Altres projectes

Veure projectes passats

COMBACTE

Combatent la Resistència Bacteriana a Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.