Epidemiologia molecular de la función pulmonar: un abordaje integral

Durada: 2010-2012
Coordinador: Stefano Guerra
Finançadors: Fondo de Investigación Sanitaria (FIS)

Sabem que els nivells de funció pulmonar constitueixen un predictor important del deteriorament funcional, de la reducció de la qualitat de vida i de la mortalitat. Això s'explica principalment pels efectes nocius de la malaltia pulmonar obstructiva crònica (MPOC). Encara que la majoria dels pacients desenvolupen la MPOC a l'edat adulta mitjana-avançada, l'acceleració del declivi de la funció pulmonar que comportarà el desenvolupament de la MPOC sol iniciar a l'edat adulta jove. D'aquesta manera, la identificació de biomarcadors sistèmics del declivi de la funció pulmonar a l'edat adulta jove podria ajudar-nos a comprendre els mecanismes moleculars de susceptibilitat primerenca en la MPOC i tenir implicacions crítiques per a la seva prevenció. Proposem utilitzar la branca espanyola de l'estudi European Communnity Respiratory Health Survey, basat en la població (N = 1595), que ofereix informació respiratòria fenotípica detallada i una gran quantitat de mostres de sèrum i ADN. Realitzarem proves en sèrum tant amb tecnologia MAP obtinguda a partir de Luminex, com en ELISA, amb un panell de 14 biomarcadors implicats variablement en la inflamació (IL-1beta, IL-6, IL-8, TNF-alfa, CRP), immunitat innata ( sCD14), proteòlisi (alfa1 antitripsina, TIMP1, MMP3), estrès oxidatiu (mieloperoxidasa), respostes autoimmunes (anticossos antielastina) i altres rutes potencials (YKL-40, CC-16, SP-D). També es farà el genotipatge de nombrosos escombraries candidats relacionats amb aquests biomarcadors. Finalment, es contrastarà de forma prospectiva la relació entre els nivells de biomarcadors i les variants genètiques i els nivells i el declivi de la funció pulmonar per obtenir els perfils moleculars de la susceptibilitat a la MPOC.

Investigador principal (IP)

Stefano Guerra Visiting Scholar

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