Investigación, Chagas

ChagasLAMP (GHIT G2020-203)

Field validation of Trypanosoma cruzi-LAMP: a molecular point-of-care test for the control of congenital Chagas disease

A young Bolivian girl is tested for Chagas disease
Foto: Ana Ferreira
01/04/2021 - 31/03/2023
Julio Alonso
Global Health Innovative Fund (GHIT)

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects ~7 million people, mostly in Latin America. Vector-borne transmission is on the way of being controlled in several countries, but vertical transmission remains an uncontrolled major public-health challenge. Remarkably, available drugs have a very high cure rate in T. cruzi-infected newborns if administered early upon infection, thus a timely diagnose is crucial for treatment success.

However, the algorithm to detect congenital T. cruzi infection involves parasitological methods that lack sensitivity and a serological study must be performed several months later. In many endemic regions, people live far from referral centres which entails that a large proportion of infants rarely go back for diagnosis confirmation and treatment, if infected. Consequently, they evolve to the chronic phase of the disease with the risk of developing severe manifestations.

Molecular-based diagnostics have a very high sensitivity to detect congenital T. cruzi infections, but laboratories in those distant regions are not equipped to perform them. With the aim to provide a suitable point-of-care (POC) test for the timely diagnosis of congenital Chagas disease in these settings, we will validate the implementation of EIKEN T. cruzi loop-mediated isothermal amplification (LAMP) prototype in the field.

Total Funding

¥ 147,127,368

Nuestro equipo


ISGlobal Team

Ver más

Otros proyectos

Ver proyectos pasados


Nuevas Herramientas para el Diagnóstico y la Evaluación del Paciente con Enfermedad de Chagas

Control of Leishmaniasis. From bench to bedside and community


Grup de recerca en patología importada i malaties emergents i re-emergents


Biomarcadores inmunológicos antígeno-específicos (células T) asociados al control de la infección por T. cruzi


Modelo y Herramienta para la construcción de estrategias para el incremento de la atención en Chagas


Towards the interruption of transmission of soil-transmitted helminths


Nuevos regímenes de quimioterapia y biomarcadores para la enfermedad de Chagas


Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.


Equidad y Optimización del Acceso al Diagnóstico y Tratamiento de la COVID-19 en Bolivia y Paraguay