- 01/01/2020 - 30/06/2021
- Cristina Villanueva Belmonte
- Ajuntament de Barcelona, "la Caixa" Foundation
Drinking water may contain emerging contaminants related to chronic diseases and ageing.
Evaluate exposure to emerging pollutants in drinking water in Barcelona.
- Measure perfluorinated substances (PFASs), bisphenol A (BPA), nonylphenol (NP), haloacetic acids (HAAs), chlorite and chlorate in drinking water.
- Create a map of the concentrations in Barcelona;
- Estimate the contribution of drinking water on the internal dose of PFASs and trichloroacetic acid;
- Measure neurotoxicity in drinking water;
- Quantify the contribution of PFASs, BPA, NP, HAAs, chlorite and chlorate on the in vitro neurotoxicity.
Descriptive study in Barcelona. 42 points (one per zip code) will be defined to take a sample of tap water. 10 samples of bottled water will be included, selecting the most popular brands, and 10 samples of filtered tap water (5 from reverse osmosis and 5 from filter jar).
The concentration of PFASs, BPA, NP, HAAs, chlorite and chlorate will be measured using sensitive methods based on chromatography and mass spectrometry.
Urine samples will be taken in 42 volunteers living in the homes sampled to measure PFASs and trichloroacetic acid, and the relative contribution of drinking water to urine levels will be estimated.
A generalized additive model will be applied to predict the level of PFASs, BPA, NP, HAAs, chlorite and chlorate at all points in Barcelona based on the levels measured.
In a subsample (N = 30) in vitro tests will be applied to estimate neurotoxicity in water samples using human neuroblastoma SH-SY5Y cells. The contribution of the different chemicals analyzed on each of the responses in vitro will be estimated using regression models.
AiguaBCN is a collaborative project led from ISGlobal in collaboration with IDAEA-CSIC (Dra. Cintia Flores, Dr. Josep Caixach, Dra. Marinella Farré), URV-Tecnatox (Dra. Marta Schuhmacher, Dr. Joaquim Rovira), ICRA (Dr. Maria José Farré), and UFZ (Dr. Beate Escher).
First complete information on exposure to emerging compounds in drinking water in Barcelona, with the potential to assess effects related to ageing in the population.
How to participate
Otros proyectosVer proyectos pasados
Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España
Aging Lungs in European Cohorts
Physical Activity as a Crucial Patient Reported Outcome in COPD
Social and environmental determinants of physical activity in patients with chronic obstructive pulmonary disease (COPD): a qualitative and quantitative epidemiological study
Network on the Coordination and Harmonisation of European Occupational Cohorts
Impact Of Pollution on Asthma and Rhinitis
Integrating Environment and Health Research: a Vision for the EU
Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors
Valorización del Archivo Europeo del Genomas y Fenomas (EGA) para la Industria y la Sociedad
Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement
Cohorte Covid-19 en Cataluña
Signs of Early Adaptation to Climate Change
Las Voces de los Afectados por la Nefropatía Mesoamericana
Co-created educational programme for dyspnea-bearing patients and their caregivers
Risk of colorectal and breast cancer with widespread drinking water chemical contaminants