HORMONIT
Molecular Epidemiological Study on Hormonal Changes Associated with Circadian Disruption in Night Shift Workers
- Duration
- 2015-2019
- Coordinator
- Manolis Kogevinas
- Funded by
- Instituto de Salud Carlos III - FEDER (PI14/00444)
Night shift work has been associated with cancer risk, but the biological mechanisms are not well established. The HORMONIT study will evaluate the effects of circadian disruption due to night shift work on the production and timing of sex steroid hormones, the production of cytokines, and the metabolomic profile of night shift workers.
Approximately 60 male, rotating shift workers will be included in the HORMONIT study, funded partially by the Instituto de Salud Carlos III-FEDER (PI14/00444). All participants will be sampled twice on two working days (one during their day shift rotation and another during their night shift rotation). During each of the two days of data collection, all urine voids will be collected for 24 h, continuous personal measurements of light will be made, multiple blood samples will be extracted, and participants will respond to a baseline and separate day shift and night shift questionnaires.
The study will provide evidence on molecular and hormonal mechanisms to explain the increase in cancer and other common non-communicable diseases among night shift workers. It will also allow us to establish recommendations on optimal patterns for workers based on experimental evidence.
Questionnaires
- General Questionnaire - Luminosity Study (in Spanish)
- Full Questionnaire - Morning (In Spanish)
- Full Questionnaire - Night (in Spanish)
Publications
- Harding BN, Castaño-Vinyals G, Palomar-Cros A, Papantoniou K, Espinosa A, Skene DJ, Middleton B, Gomez-Gomez A, Navarrete JM, Such P, Torrejón A, Kogevinas M, Pozo OJ. Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study. Scand J Work Environ Health 2022;48(1):41-51. doi:10.5271/sjweh.3991 | Published online: 08 Oct 2021, Issue date: 01 Jan 2022
Our Team
Coordinator
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Manolis Kogevinas Research Professor
ISGlobal Team
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Lourdes Arjona Lab Manager and Research Technician -
Gemma Castaño Staff Scientist -
Ana Espinosa Statistician
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