Research

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Duration: June 2019- May 2024
Coordinator: Isabelle Thierry Chef
Funded by: Horizon2020 (EC)

The use of radiation for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques largely outweigh the risks, there is a need to better understand the long-term health effects of such exposures in order to optimise treatment plans in these young patients and reduce the risk of late toxicities.

Overall Goal

HARMONIC aims at better understanding the long-term health effects of medical exposure to ionising radiation in children, specifically those undergoing radiotherapy for cancer or X-ray guided imaging for cardiac interventions.

The European-funded project consortium is composed of 24 European partners and led by ISGlobal.

Specific Aims

By building European cohorts and registries for long-term follow up of paediatric patients, we aim to:

Investigate the late health effects in children undergoing modern radiotherapy (including proton therapy)
Investigate development of cancer in children exposed to X-ray guided imaging for treatment of cardiac disorders
Provide the medical and radiation protection (RP) communities with tools for long-term follow-up of children exposed to medical ionising radiation.
Improve estimates of radiation doses received by different organs in the body during these procedures
Investigate possible mechanisms that may lead to the development of cancer and vascular diseases in these patients later in life
Establish recommendations to optimise these techniques and further reduce radiation doses received by children undergoing X-ray guided imaging and radiotherapy

Expected Impact

HARMONIC will provide much-needed information on the effects of low to moderate doses of radiation on humans and help improve radiological protection in medicine.

The 5-year project is based on building a close relationship with clinicians (paediatric oncologists and cardiologists), sociologists, and patients, which will ensure the study is relevant not only in terms of clinical effectiveness but also in terms of patient care and quality of life.