Clinical trial of new drug for chronic Chagas disease
Phase II multicenter, randomized, placebo-controlled study of the safety and efficacy of three oral dosing regimens of E1224 and benznidazole in adult patients with chronic indeterminate Chagas disease
E1224 is a prodrug of ravuconazole developed by Eisai Pharmaceuticals. It is administered orally and has been shown to have potent activity against the parasite responsible for Chagas disease. It also has several other properties that make it a promising candidate for the treatment of Chagas disease, including good absorption and tolerability profiles, once-weekly administration, and an affordable price.
The drug is being tested in a phase II study conducted by ISGlobal, in conjunction with the Platform for the Integral Care of Patients With Chagas Disease, a collaborative project involving CEADES (a Bolivian NGO), Universidad Mayor de San Simón de Cochabamba, and Universidad Autónoma Juan Misael Saracho (Tarija). This phase II proof-of-concept study will analyse the potential of E1224 as an oral, easy-to-use, safe, and affordable treatment for Chagas disease. The project is being coordinated by the Drugs for Neglected Diseases Initiative and funded by the Wellcome Trust.
The study will also investigate several biomarkers that may help to assess disease cure and treatment success in patients with chronic Chagas disease and serve as valuable tools in future clinical trials of E1224 and other new drugs. The current lack of early markers of treatment response is a major obstacle in the fight against Chagas disease.
Enlaces de interés
Other projects
See Past ProjectsNHEPACHA
New Tools for the Diagnosis and Evaluation of Chagas Disease
RTS,S Vaccine Immunology Study
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial
Euroleish.net
Control of Leishmaniasis. From bench to bedside and community
GREPIMER
Grup de recerca en patología importada i malaties emergents i re-emergents
TESEO
New chemotherapy regimens and biomarkers for Chagas Disease
ASINTMAL
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
ADAM
Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation
MULTIPLY
MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention
Science4Pandemics
Citizens engagement digital platform for collective intelligence in pandemics
HIDDENVIVAX
Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
Herramienta innovadora de detección de enfermedades y vacunación a población inmigrante en riesgo en España
Project Code: PI21/00651
Impacto de las coinfecciones en el balance de respuestas de anticuerpos y linfocitos T helper a antígenos diana de inmunidad natural y vacunal frente a patógenos humanos prominentes
Project Code: PI20/00866
EpiGen
Building Scalable Pathogen Genomic Epidemiology in Ethiopia
MalTransc
Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses
BOHEMIA
Broad One Health Endectocide-based Malaria Intervention in Africa
RESPONSE
Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum
VivaxEVTalk
Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria
VaMonoS
Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria
CLIMSOCTRYPBOL
Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.
SexMal
Social affairs and sex in P. falciparum: implications for malaria elimination
MENA Migrant Health
Transforming data collection and surveillance to drive migrant health research, care and policy
MESA
Sharing knowledge and catalyzing research towards a malaria-free world
GenMoz
P. falciparum genomic intelligence in Mozambique
SMART
Identifying Severe Malaria with a new Aptamer-based Rapid diagnostic Test