- 01/04/2021 - 31/03/2023
- Julio Alonso
- Funded by
- Global Health Innovative Fund (GHIT)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects ~7 million people, mostly in Latin America. Vector-borne transmission is on the way of being controlled in several countries, but vertical transmission remains an uncontrolled major public-health challenge. Remarkably, available drugs have a very high cure rate in T. cruzi-infected newborns if administered early upon infection, thus a timely diagnose is crucial for treatment success.
However, the algorithm to detect congenital T. cruzi infection involves parasitological methods that lack sensitivity and a serological study must be performed several months later. In many endemic regions, people live far from referral centres which entails that a large proportion of infants rarely go back for diagnosis confirmation and treatment, if infected. Consequently, they evolve to the chronic phase of the disease with the risk of developing severe manifestations.
Molecular-based diagnostics have a very high sensitivity to detect congenital T. cruzi infections, but laboratories in those distant regions are not equipped to perform them. With the aim to provide a suitable point-of-care (POC) test for the timely diagnosis of congenital Chagas disease in these settings, we will validate the implementation of EIKEN T. cruzi loop-mediated isothermal amplification (LAMP) prototype in the field.
Julio Alonso Assistant Research Professor
Aina Casellas Técnico de Soporte Estadístico
Laura Ferradino Research Assistant
Quim Gascon Research Professor, Head of the Chagas, Parasitic and Imported Diseases programme
Susana Méndez Data manager
Mirko Rojas Consultant and Field Coordinator in Bolivia
Sergi Sanz Head of Department - Statistics
Arantxa Sarrà Técnico Gestión Paralegal
Monica Solanes Desk Manager
Other projectsSee Past Projects
New Tools for the Diagnosis and Evaluation of Chagas Disease
Control of Leishmaniasis. From bench to bedside and community
Grup de recerca en patología importada i malaties emergents i re-emergents
Investigación aplicada al diagnóstico y tratamiento de los virus Zika, Dengue y Chikunguña
Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.
Model and Tool for designing strategies to scale up Chagas Disease care
Towards the interruption of transmission of soil-transmitted helminths
New chemotherapy regimens and biomarkers for Chagas Disease
Improving health data collection under the healthcare programme for migrant population in Nador, Morocco
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Enhanced and equitable coverage of COVID-19 testing and treatment in Bolivia and Paraguay