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ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

ANSES HyPAXE Project
Duration
13/11/2019 - 12/05/2023
Coordinator
Jordi Sunyer
Funded by
ANSES - Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail

This project is in line with the Developmental Origins of Health and Diseases (DOHaD) hypothesis suggesting that exposure to adverse environmental conditions during early life can affect short but also long term health outcomes. In the HyPAxE project, we hypothesize that exposure to short halflife endocrine disruptors during pregnancy can induce dysregulation of the I-IPA axis during critical periods of brain development which, in turn, could lead to neurodevelopmental disorders later in life.

Objectives

The HyPAxE project aims to:

  • test whether prenatal exposure to a family of endocrine disruptors (phenols) is associated with child neurodevelopment (including cognition, motricity and dysregulated behaviour);
  • explore the associations between exposure to phenols and dysregulation of the hypothalamic-pituitary-adrenal (I-IPA) axis functioning;
  • characterize the contribution of dysregulation of the I-IPA axis functioning in the associations of phenols and child neurodevelopment.


Figure 3: Aims of the HyPAxE project

Total Funding

32.490 €

Our Team

Coordinator

ISGlobal Team

  • Payam Dadvand
    Payam Dadvand
  • Martine Vrijheid
    Martine Vrijheid Research Professor and Head of the Environment and Health over the Lifecourse Programme

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