Streptococcus agalactiae

Durada

2014 - 2017

Coordinador

Sara Soto

Finançadors

Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

Neonatal sepsis is a major but undervaluated problem worldwide.

Streptococcus agalactiae is the microorganism most frequently associated with neonatal sepsis in developed and low income countries. In countries which have implemented preventive measures against the SGB, recommended by the CDC, cases of neonatal sepsis caused by this organism have decreased but the late neonatal sepsis cases still in their levels.

The project's objectives are to study the epidemiology, levels of antimicrobial resistance and the presence of virulence factors in strains; identify bacterial factors related to vertical transmission of bacteria from mother to child, and determine the relationship between time colonization, presence and levels of antibodies and risk of late neonatal sepsis.

To accomplish these objectives phenotypic (antibiogram, translocation) and genotypic techniques (PCR, cloning, mutagenesis, secretome) will be used that allow us to further characterize this organism and determine the basis for its transmisison vertically.

The data will be important in the detection, prevention, treatment and vaccination against this microorganism.

Project Code

PI13/00127