HIDDENVIVAX
Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria
- Duración
- October 1st 2021 - October 1st 2024
- Coordinador
- Hernando A. del Portillo Obando
- Financiadores
- “la Caixa” Foundation
- Página web
- https://hiddenvivax.com/
Infectious diseases, many of them forgotten, kill 17 million people every year in the poorest regions on the planet. One such disease is malaria caused by the world’s most widely distributed malaria parasite, Plasmodium vivax.
One of the many unanswered questions is the origin of asymptomatic chronic infections with numerous epidemiological field studies supporting >90% of such infections. One hypothesis is that nanovesicles called exosomes, mediate cryptic infections in the human bone marrow and spleen, with clear implications for malaria elimination.
This project aims to develop a miniature model of human bone marrow and spleen (organ-on-a-chip technology) to investigate the parasite’s hiding places in the organism, uncover the role of the exosomes and eliminate malaria.
Total Funding
996,930.57 euro
Nuestro equipo
Coordinator
-
Hernando A. Del Portillo ICREA Research Professor
ISGlobal Team
-
Carmen Fernández Associate Research Professor -
Núria Sima Investigadora posdoctoral -
Oscar Castillo Investigador posdoctoral
-
Marc Nicolau Técnico de Laboratorio
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