Investigación, Eliminación de la malaria

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

Duración: October 1st 2021 - October 1st 2024
Coordinador: Hernando A. del Portillo Obando
Financiadores: “la Caixa” Foundation
Página web: https://hiddenvivax.com/

Infectious diseases, many of them forgotten, kill 17 million people every year in the poorest regions on the planet. One such disease is malaria caused by the world’s most widely distributed malaria parasite, Plasmodium vivax.

One of the many unanswered questions is the origin of asymptomatic chronic infections with numerous epidemiological field studies supporting >90% of such infections. One hypothesis is that nanovesicles called exosomes, mediate cryptic infections in the human bone marrow and spleen, with clear implications for malaria elimination.

This project aims to develop a miniature model of human bone marrow and spleen (organ-on-a-chip technology) to investigate the parasite’s hiding places in the organism, uncover the role of the exosomes and eliminate malaria.

Total Funding

996,930.57 euro

Coordinator

Hernando A. del Portillo ICREA Research Professor

ISGlobal Team

Carmen Fernández Associate Research Professor
Núria Sima Investigadora posdoctoral
Oscar Castillo Investigador posdoctoral
Marc Nicolau Técnico de Laboratorio

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Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults

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Total Funding

Nuestro equipo

Coordinator

ISGlobal Team

Otros proyectos

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