Investigación Programas

ENDOLUNG

Endocrine Disruptors and Childhood Lung Function and Asthma

Duración
2017-2019
Coordinador
Maribel Casas (ISGlobal)
Financiadores
Instituto de Salud Juan Carlos III - Unión Europea

Background

Endocrine-disrupting chemicals (EDCs), widely used in many consumer products, can alter lung development and increase the risk of childhood asthma. There are currently very few prospective studies and they have focused on the effects of bisphenol A (BPA), although there are many other phenolic compounds that can interfere with the developing respiratory system. The rapid increase of asthma prevalence and the widespread exposure to EDCs have raised concerns about their potential role in asthma development.

Aim

ENDOLUNG aims to examine whether pre and postnatal exposure to EDCs, specifically phenolic compounds including BPA, influence childhood lung function and asthma through early adolescence.

Methods

The project will use several existing population-based birth cohort studies: the Spanish INMA, the Dutch GENERATION R, and the European HELIX cohort, including a total of 2566 mother-child pairs. The project will develop a comprehensive exposure assessment for EDCs by analyzing them in repeated urine samples collected during pregnancy and childhood. ENDOLUNG will develop a novel asthma phenotype characterization by constructing longitudinal growth trajectories of lung function through early adolescence and by using different instruments including asthma symptoms, fractional exhaled nitric oxide, and reversibility test. The team will study the role of systemic inflammation and oxidative stress in the association between phenolic compounds and lung function and asthma.

Implications

ENDOLUNG will be the first and the largest study so far combining data from different European countries and is expected to strongly contribute to the evidence of presence or absence of effects of EDCs on respiratory health.

Total Funding

121.500 euros.

 

Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

 

Nuestro equipo

Principal Investigator (PI)

  • Maria Isabel Casas Sanahuja
    Maria Isabel Casas Sanahuja

Otros proyectos

Ver proyectos pasados

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

APACHE

Air Pollution, Autism spectrum disorders, and brain imaging in CHildren amongst Europe

LIFECYCLE

Early-life stressors and LifeCycle health

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

MOOD-COVID

Pre- and post-natal Maternal mental health and newbOrn neurOdevelopment during the COVID-19 panDemic

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

The Lungfit Project

Socioeconomic Status, Physical Activity, and Respiratory Health in Pregnant Women, Children, and Adolescents

ExPEC-TEEN

Prenatal Exposure to Environmental Pollutants and Metabolic and Cardiovascular Health of the Teenagers

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

HELIX-NAFLD

Developmental origins of child liver injury: the effect of early life environmental exposures

UrbaMet

Entorno Urbano y Salud Cardiometabólica desde el Nacimiento hasta la Adolescencia

NutriPROGRAM

Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

ELHNA

Exposures to light pollution and heat, and neurodevelopment in adolescents

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

FRONTIER

Traffic-Related Air Pollution and Birth Weight: the Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status

The APBO Project

Air Pollution and Birth Outcomes: Windows of Exposure and Health and Economic Impact Assessment

INMA-Ado-Sueño

Radio Frequency Electromagnetic Fields, Noise, and Sleep Disorders in Adolescence

ANSES HyPAXE

Prenatal Exposure to a Family of Short Half-Life Endocrine Disruptors, Dysregulation of the Hypothalamic–Pituitary–Adrenal Axis and Potential Implication for Child Neurodevelopment at Early Age

EXPO-ENFANTS

Caractérisation des usages et de l’exposition aux radiofréquences induite par les dispositifs de communication mobiles chez les enfants

Lily

Light at Night Exposure and Sleep Quality

EMBRYORAD

Radiofrequency Electromagnetic Fields, Other Environmental Factors, and Development of the Embryo and Fetus

IGRO

The Impact of Maternal-Fetal Steroid Metabolome Exposure on Child GROwth and Neurological Outcomes

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

ALTER

Air Pollution, Gut Microbiota and Neurodevelopment in the First 24 Months of Life

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment