Tuberculosis

(Alberto García-Basteiro)

Overview
Publications

The current WHO strategy (END-TB) aims to reduce TB incidence and TB mortality by 90 and 95% respectively by 2035 (as compared to 2015). This acceleration in TB control efforts will not be possible without an improved TB vaccine. In addition to the development and implementation of an effective vaccine, the development of new point of care tests, shorter treatment regimens for drug susceptible and drug resistant TB, and improved access to testing, are key elements which will pave the road to achieving global control / elimination targets.

The mycobacterial infections caused by Non-Tuberculous Mycobacteria (NTM) are experimenting an increase in incidence worldwide, especially in patients with chronic pulmonary disease as COPD or bronchiectasis, being cause of morbidity and continuous treatment during years, without a clear perspective of curation.

With whom do we colaborate

Main research lines

Determine disease burden in vulnerable populations (children, HIV-infected, pregnant)
Assess the impact of innovative strategies for the active search for cases based on spatial parameters, population density and microbial load in index cases
Evaluate new diagnostic tools in contexts of high prevalence of TB and HIV
Evaluate new biomarkers for the diagnosis and treatment of TB

Mariner-Llicer C, Goig GA, Torres-Puente M, Vashakidze S, Villamayor LM, Saavedra-Cervera B, Mambuque E, Khurtsilava I, Avaliani Z, Rosenthal A, Gabrielian A, Shurgaia M, Shubladze N, García-Basteiro AL, López MG, Comas I. Genetic diversity within diagnostic sputum samples is mirrored in the culture of Mycobacterium tuberculosis across different settings. Nat Commun 2024;15(1):7114.
Centner CM, Munir R, Tagliani E, Rieß F, Brown P, Hayes C, Dolby T, Zemanay W, Cirillo DM, David A, Schumacher SG, Denkinger CM, Ruhwald M, Leukes VN, Nicol MP, Van der Walt I, Kisten G, Gumede M, Mace A, Brink A, Stevens W, Scott L, Penn-Nicholson A, Cox H; TB-CAPT Consortium (including Garcia-Basteiro AL). Reflex Xpert MTB/XDR Testing of Residual Rifampicin-Resistant Specimens: A Clinical Laboratory-Based Diagnostic Accuracy and Feasibility Study in South Africa. Open Forum Infect Dis 2024;11(8):ofae437.
Mangu C, Cossa M, Ndege R, Khosa C, Leukes V, de la Torre-Pérez L, Machiana A, Kivuma B, Mnzava D, Zachariah C, Manjate P, Tagliani E, Schacht C, Buech J, Singh S, Ehrlich J, Riess F, Sanz S, Kranzer K, Cox H, Sabi I, Nguenha D, Meggi B, Weisser M, Ntinginya N, Schumacher S, Ruhwald M, Penn-Nicholson A, Garcia-Basteiro AL; TB-CAPT Consortium. Expanding Xpert MTB/RIF Ultra® and LF-LAM testing for diagnosis of tuberculosis among HIV-positive adults admitted to hospitals in Tanzania and Mozambique: a randomized controlled trial (the EXULTANT trial). BMC Infect Dis. 2024;24(1):831
Churchyard GJ, Houben RMGJ, Fielding K, Fiore-Gartland AL, Esmail H, Grant AD, Rangaka MX, Behr M, Garcia-Basteiro AL, Wong EB, Hatherill M, Mave V, Dagnew AF, Schmidt AC, Hanekom WA, Cobelens F, White RG. Implications of subclinical tuberculosis for vaccine trial design and global effect. Lancet Microbe 2024:S2666-5247(24)00127-7.
Gómez-Valverde JJ, Sánchez-Jacob R, Ribó JL, Schaaf HS, García Delgado L, Hernanz-Lobo A, Capellán-Martín D, Lancharro Á, Augusto O, García-Basteiro AL, Santiago-García B, López-Varela E, Ledesma-Carbayo MJ. Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study. JMIR Pediatr Parent 2024:7:e51743.
Martinez L, Seddon JA, Horsburgh CR, Lange C, Mandalakas AM; TB Contact Studies Consortium (including Garcia-Basteiro AL). Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies. Lancet Respir Med. 2024:S2213-2600(24)00083-3.
Garcia-Basteiro AL, Ehrlich J, Bonnet M, Calnan M, Graham SM, Hermans S, Jarrett A, Lewa R, Mandalakas A, Martinez L, Migliori GB, Ong CWM, Otero L, Rangaka MX, Raviglione MCB, Seaworth B, Ssengooba W, Theron G, Trajman A, Behr MA. A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis. Lancet Glob Health 2024:S2214-109X(24)00083-4.
Sequera G, Estigarribia-Sanabria G, Aguirre S, Piñanez C, Martinez L, Lopez-Olarte R, Andrews JR, Walter KS, Croda J, Garcia-Basteiro AL. Excess tuberculosis risk during and following incarceration in Paraguay: a retrospective cohort study. Lancet Reg Health Am 2024:31:100668
Martín Pérez C, Aguilar R, Jiménez A, Salmerón G, Canyelles M, Rubio R, Vidal M, Cuamba I, Barrios D, Díaz N, Santano R, Serra P, Santamaria P, Izquierdo L, Trilla A, Vilella A, Barroso S, Tortajada M, García-Basteiro AL, Moncunill G, Dobaño C. Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination BMC Med 2024 ;22(1):103.
Kay A, Vasiliu A, Carratala L, Mtafya B, Mendez Reyes JE, Maphalala N, Munguambe S, Mulengwa D, Ness T, Saavedra B, Bacha J, Maphalala G, Mejia R, Mtetwa G, Acacio S, Manjate P, Mambuque E, Shiba N, Kota N, Ziyane M, Elias NN, Lange C, Kirchner HN, DiNardo AR, Garcia-Basteiro AL, Mandalakas AM, for the Stool4TB Global Partnership. Performance of a stool-based quantitative polymerase chain reaction assay for the diagnosis of tuberculosis: a multinational prospective study of diagnostic accuracy in adolescents and adults. The Lancet Microbe 2024:S2666-5247(23)00391-9.
Carratala-Castro L, Ssengooba, Kay, Acácio S, Ehrlich J DiNardo AR, Shiba N, Nsubuga JK, Munguambe S, Saavedra B, Mandjate P, Mulengwa D, Sibandze B, Ziyane M, Kasule, Mambuque E, Sekadde MP, Wobudeya E, Joloba ML, Heyckendorf J, Lange C, Hermans S, Mandalakas A, García-Basteiro AL, Lopez-Varela E on behalf of Stool4TB Global Partnership. A Stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation. BMC Infec Dis, 2024. 24(1):233.
Sequera G, Aguirre S, Estigarribia G, Walter KS, Horna-Campos O, Liu YE, Andrews JR, Croda J, Garcia-Basteiro AL. Incarceration and TB: the epidemic beyond prison walls. BMJ Glob Health 2024;9(2):e014722
Saavedra B, Nguenha D, de la Torre-Pérez L, Mambuque E, Tembe G, Oliveras L, Rudd M, Philimone P, Jose B, Garcia JI, Gomes N, Munguambe S, Chiconela H, Nhanommbe M, Izco S, Acacio S, García-Basteiro AL. Improving tuberculosis case detection through contact risk stratification by Xpert MTB/RIF Ultra and spatial parameters: evaluation of an innovative active case finding strategy in Mozambique (Xpatial-TB). PLOS Glob Public Health. 2024: 4(2):e0002789
Cossa M, Nguenha D, Houana A, Ehrlich J, Acácio S, Garcia-Basteiro AL. The urgent need to improve on low implementation rates for TB preventive treatment for people living with HIV. Int J Tuberc Lung Dis 2024: 28(1):1-2.
White RG, Fiore-Gartland AJ, Hanekom WA, Vekemans J, Garcia-Basteiro AL, Churchyard G, Rangaka MX, Frick M, Behr MA, Hill PC, Mave V. What is next for BCG revaccination to prevent tuberculosis? Lancet Respir Med 2024 :S2213-2600(24)00009-2.
Leukes VN, Hella J, Sabi I, Cossa M, Khosa C, Erkosar B, Mangu C, Siyame E, Mtafya B, Lwilla A, Viegas S, Madeira C, Machiana A, Ribeiro J, Garcia-Basteiro AL, Riess F, Elísio D, Sasamalo M, Mhalu G, Denkinger CM, Castro MDM, Bashir S, Schumacher SG, Tagliani E, Malhotra A, Dowdy D, Schacht C, Buech J, Nguenha D, Ntinginya N, Ruhwald M, Penn-Nicholson A, Kranzer K; TB-CAPT Consortium. Study protocol: a pragmatic, cluster-randomized controlled trial to evaluate the effect of implementation of the Truenat platform/MTB assays at primary health care clinics in Mozambique and Tanzania (TB-CAPT CORE). BMC Infect Dis. 2024: 19;24(1):107
Mariner-Llicer C, Saavedra Cervera B, Mambuque E, Gomes N, Munguambe S, Villamayor L, Cancino-Muñoz I, Torres-Puente M, Nguenha D, Respeito D, Tembe G, López MG, Comas I, García-Basteiro AL. Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique. Clin Infect Dis, 2024;78(4):842-845.
Hill PC, Cobelens F, Martinez L, Garcia-Basteiro AL, Behr M, Rangaka MX, Churchyard G, Evans T, Hanekom W, White R. Correspondence Regarding: McShane H. Improving TB vaccine trial efficiency: A tough nut to crack. J Infect Dis 2024;229(2):616.

Here you will find all publications between 2014 and 2024:

Research Programme Global Viral and Bacterial Infections
Manhiça Tuberculosis Initiative
Global Tuberculosis Dictionary A consensus glossary to unify TB vocabulary
Health Is Global Blog Posts on tuberculosis

Team

Leadership

Alberto García-Basteiro Research Professor

ISGlobal team

Elisa López Varela Associated Researcher

Belén Saavedra Associated Researcher

Clara Suñer Postdoctoral fellow

Lucía Carratalá Medical Research Fellow

Joanna Ehrlich Project manager

Belén Zachow Medical Research Fellow

Pedro Corral Financial advisor

Dora Stojanovic Project Assistant

Dinis Bento Nguenha Research assistant

Edson Mambuque Predoctoral Researcher

Marc Bañuls Data Manager

GUILLERMO MENA Associated researcher

Pau Benito Buch

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Tuberculosis

With whom do we colaborate

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