- June 2017 - September 2019
- Alberto García-Basteiro
- USAID / KNCV
This study is a parallel, two part, open label, individually randomized, pragmatic clinical trial to assess different alternatives to prevent tuberculosis (TB) among HIV-positive individuals. Part A compares a single round of weekly high dose rifapentine plus isoniazid for three months (3HP) to six months of daily isoniazid (6H). Part B compares periodic 3HP (p3HP) to a single round of 3HP.
This clinical trial aims to improve (shorten and simplify) currently available tools to prevent tuberculosis among HIV-positive individuals. The current recommendation is to provide single dose isoniazid daily during 6 months among HIV-positive individuals in whom TB disease has been ruled out. However, the implementation of this recommendation is limited in high burden countries, mostly due to adherence hurdles derived from such lengthy prophylaxis.
The study aims to enroll 4000 participants from three different countries: South Africa, Mozambique and Ethiopia. In Mozambique, the only participating site will be the Centro de Investigação em Saude de Manhiça (CISM).
1.6 million Euros
Alberto García-Basteiro Assistant Research Professor
Otros proyectosVer proyectos pasados
Combatiendo la Resistencia Bacteriana en Europa
Erradicación del Pianhttp://pian.isglobal.org
Application to medical deviceswww.nomorfilm.eu
Combatting Bacterial Resistance in Europe - Carbapenem Resistancehttps://www.imi.europa.eu/content/combacte-care
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Desarrollo de nuevos metaloantibióticos frente a patógenos causantes de infecciones crónicas en pacientes con fibrosis quística
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africahttp://inteafrica.org/
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Linkage and retention in care following home-based HIV testing serosurveys in Manhiça District, Southern Mozambique
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant womenwww.mamahproject.net