Research Programmes
Research, Maternal, Child and Reproductive Health

HIV drug resistance (HIVDR)

Description of HIV drug resistance patterns and its association with the risk of HIV mother to child transmission among pregnant women from southern Mozambique

Duration
01/01/2023 - 31/12/2025
Coordinator
Raquel González
Funded by
Instituto de Salud Carlos III

HIV drug resistance (HIVDR) can compromise the effectiveness of antiretroviral therapy (ART), which is particularly important among pregnant women from sub-Saharan Africa due to the high burden of infection in the region and the risk of HIV mother to child transmission (MTCT).

Objective

To describe the prevalence and characteristics of HIVDR mutations among Mozambican pregnant women before and after dolutegravir (DTG) scale up in the country, and to evaluate its association with the risk of MTCT of HIV through breastfeeding.

Methods

Plasma samples from 200 HIV-infected pregnant women with virological failure (HIV viral load> 50 c/ml) will be analyzed. HIVDR will be determined using MiSeq® in samples collected at the first antenatal care visit and at delivery. In a sub-sample of participants, the presence of HIV in breastmilk will also be analyzed.

Total Funding

123,000 EUR

 

 

Our Team

Coordinator

ISGlobal Team

Other projects

See Past Projects

CaDMIA-plus

Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death

TIPTOP

Transforming IPT for optimal pregnancy

METRO

Measuring community prevalence among HIV exposed children in rural Southern Mozambique

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

MIBio

Identification of Prematurity and Pre-Eclampsia as Causes of Mortality

STREESCO

Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19

MULTIPLY

MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention

MA-CoV

Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations

IPERVAC-SL

Impact of perceptions of COVID-19 vaccines on health-seeking behaviours in Sierra Leone

RESPIRE

Respiratory syncytial virus (RSV) in African pregnant women and children

VITAL

Towards preparedness for new maternal vaccinations: Understanding barriers and facilitators to maternal vaccine acceptance