Research

CORSAIR

Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors

Stethoscope
Photo: Rawpixels
Duration
01/03/2020 - 01/02/2021
Coordinator
Judith Garcia Aymerich
Funded by
Barcelona Respiratory Network Foundation, ISGlobal and participating hospitals, and AstraZeneca

Although the majority (80%) of those infected with SARS-CoV-2 present mild coronavirus disease 2019 (COVID-19) characterized by unspecific symptoms, around 15% develop severe pneumonia requiring hospitalization, and approximately 5% (critical COVID-19) of all the infected develop severe acute respiratory failure (with or without acute respiratory distress), septic shock, and / or multiorgan failure requiring care in an intensive care unit (UCI). The evolution of the patient from a serious condition to a critical stage often occurs quickly and insidiously, so the clinicians have little time to react.

To date, it is unknown which factors, apart from aging and the presence of chronic diseases, can predict the evolution of COVID-19 from severe to critical disease. The objectives of the CORSAIR study are:

  • To estimate the association between risk factors (clinical, biological and imaging) and the development of severe respiratory failure or death in 8,000 patients hospitalized for SARS-CoV-2 infection in nine Spanish public hospitals.
  • To identify low-cost, non-invasive imaging markers (chest radiography and ultrasound), using radiology and artificial intelligence, to assess the risk of developing severe respiratory failure or dying in patients hospitalized for SARS-CoV-2 infection.

In the long term, the aim of CORSAIR is to evaluate the impact of SARS-CoV-2 infection on respiratory symptoms, lung function and structure, and biomarkers in a cohort of 500 survivors six months after discharge from hospitals.

Total funding

28,000 € in kind contrbution from ISGLobal and participating hospitals and data contribution from the Catalan Government.

Our Team

Coordinator

  • Judith Garcia
    Judith Garcia Head of the Non-Communicable Diseases and Environment Programme

ISGlobal team

Other projects

See Past Projects

MCC-Spain

Population based multicasecontrol study on common tumours in Spain

PROactive

Physical Activity as a Crucial Patient Reported Outcome in COPD

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

POLLAR

Impact Of Pollution on Asthma and Rhinitis

EPHOR

Exposome Project for Health and Occupational Research

VEIS

Leveraging the European Genome-Phenome Archive (EGA) for Industry and Society

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

COVICAT

Cohorte Covid-19 en Cataluña

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

AiguaBCN

Exposure to emerging contaminants in drinking water in Barcelona potentially liked to chronic diseases and wellbeing

Fotovoz

Las Voces de los Afectados por la Nefropatía Mesoamericana

CALMA

Co-created educational programme for dyspnea-bearing patients and their caregivers

Cancer-Watch

Risk of colorectal and breast cancer with widespread drinking water chemical contaminants

CONTENT

Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease