- 01/01/2018 - 31/12/2023
- Manolis Kogevinas
- Funded by
- ISCIII, FIS PI17/01388, FEDER
The CityExposomeCat project applied an “exposome” approach to a large cohort of adults in Catalonia (CAT) to evaluate environmental exposures and lifestyle factors that are related to urban settings, and examine their association with well being and major diseases (obesity, cardiometabolic, mental health). The project eventually expanded its objectives to include COVID-19 as a major outcome (see COVICAT cohort).
Exposome approaches ultimately allow the understanding of mechanisms of disease through the use of agnostic “omic” approaches and advanced technology in environmental epidemiology.
The CityExposomeCat focuses on the evaluation of environmental (e.g. air pollution) and lifestyle factors (e.g. sleep) and their association with health, while a companion project focuses on omics.
The GCAT cohort includes around 20,000 volunteer adults in Catalonia, mostly in urban areas that have completed a first round of questionnaires, provided biological samples and who can be identified in electronic primary and secondary health registers. Residences of all subjects were geocoded and a Geographic Information System (GIS) based approach was applied to evaluate environmental exposures (proximity to natural/green spaces, urban structure, air-pollution, noise, temperature and artificial light at night) using existing information (e.g. Urban Atlas, Landsat images).
A new follow-up was conducted in 6,000 subjects recovering additional information on environmental, lifestyle and incident health related outcomes.
A validation study was conducted in a subsample (unfortunately disrupted in March 2020 due to COVID-19) using advanced technologies for individual exposure assessment (e.g. actigraphs, light measurements) that should have allowed quantification of error and calibration of exposure assessment in the whole cohort.
Manolis Kogevinas Scientific Director of the Severo Ochoa distinction
Other projectsSee Past Projects
Cohorte Covid-19 en Cataluña
Population based multicasecontrol study on common tumours in Spain
Novel tools for integrating early-life environmental exposures and child health across Europe
Early Genetics Growth/Early Genetics and Lifecourse Epidemiology
Pregnancy and Childhood Epigenetics
Early-life stressors and LifeCycle health
Network on the Coordination and Harmonisation of European Occupational Cohorts
Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs
Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement
Signs of Early Adaptation to Climate Change
Advancing Tools for Human Early Lifecourse Exposome Research and Translation
Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities
A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health
An integrative strategy of testing systems for identification of EDs related to metabolic disorders
EXposome Powered tools for healthy living in urbAN SEttings
Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics
Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility
Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development
El impacto de la exposición al metaboloma de esteroides materno-fetales en el crecimiento infantil y los resultados neurológicos (IGRO)
Project Code: PI21/01269
The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence
ALTER - Contaminación del aire, microbiota intestinal y neurodesarrollo en los primeros 24 meses de vida
Project Code: PI21/01278
¿Es mejor consumir el agua de grifo si queremos reducir la exposición a nano/micropláticos?
Urban and social environment and childhood obesity – a natural moving2health experiment
Urban planning, environment and health
Characterization of Oral NMP Exposure
In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform
Digital Twins Enabled Indoor Air Quality Management for Healthy Living
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
The Urban Burden of Disease Estimation for POLICY Making
Exposición prenatal a sustancias poli y perfluoradas en agua de consumo y neurodesarrollo en el inicio de la vida
Project Code: PI20/00829
Project Code: PI20/01116
Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease
Drinking Water in Barcelona: Sustainability and Health Impact Assessment
Exposome Project for Health and Occupational Research