Risk of colorectal and breast cancer with widespread drinking water chemical contaminants
- 13/11/2019 - 31/12/2022
- Cristina Villanueva
- Funded by
- French Agency for Food, Environmental and Occupational Health & Safety (ANSES)
Breast and colorectal cancer rank first and third most incident cancers worldwide. Part of the burden of disease remains unexplained by the known etiological factors and some chemicals in drinking water have been suggested as risk factors.
Nitrate and disinfection by-products (DBPs) are widespread in drinking water. Nitrate originates from fertilizers used in intensive agriculture and waste from intensive farms. DPBs form a complex mixture generated in the drinking water treatment as unwanted by-products from disinfection. Trihalomethanes (THMs) are prevalent chlorination-DBPs used as a surrogate of DBP exposure in epidemiological studies. Alternative disinfectants (e.g. ozonation, chlorine dioxide) produce other DBPs (e.g. bromate, chlorite, chlorate). All of us are exposed to THMs through ingestion, inhalation or dermal absorption in showers or baths, as THMs are volatile and skin permeable.
Long-term exposure to nitrate and THMs at levels below the regulatory limits has been linked to colorectal and breast cancer. However, current knowledge is inconclusive, particularly concerning the co-exposure to nitrate and multiple DBPs.
We propose the first evaluation based on a large French population-based prospective cohort (CONSTANCES), including 200,000 subjects from areas with wide exposure variation.
Cancer-Watch aims to provide new epidemiological evidence on the association between DBPs and nitrate in drinking water with breast and colorectal cancer risk. Specifically, we will:
- 1) Ascertain drinking water source and treatment in the study areas for 1950-2019.
- 2) Model level of THMs, bromate, chlorate, chlorite, and nitrate in drinking water.
- 3) Validate current routine monitoring data with own measurements.
- 4) Estimate long-term exposure to THM, bromate, chlorite, chlorate and nitrate in the study population.
- 5) Evaluate the breast and colorectal cancer risk associated with long-term exposure to THMs, bromate, chlorate, chlorite, and nitrate, adjusting for confounders.
Cancer-Watch is a collaborative project led by ISGlobal in collaboration with INSERM U1085 (Dr. Bénédicte Jacquemin, Barbara Le Bot, Philippe Glorennec) and INSERM UMS011 (Marcel Goldberg, Marie Zins.)
Cancer-Watch will contribute to elucidate the role of widespread drinking water chemicals on the risk of highly frequent cancers in the population, thus providing relevant evidence for health risk assessment and regulation with enormous potential to reduce the burden of disease.
CRISTINA VILLANUEVA Associate Research Professor
José Antonio Alcolea Statistician
Manolis Kogevinas Scientific Director of the Severo Ochoa distinction
Sewon Lee Postdoctoral researcher
Antònia Valentín Geographical Information System (GIS) Technician
Other projectsSee Past Projects
Population based multicasecontrol study on common tumours in Spain
ALEC (Aging Lungs in European Cohorts)
Ageing Lungs in European Cohorts
Physical Activity as a Crucial Patient Reported Outcome in COPD
Network on the Coordination and Harmonisation of European Occupational Cohorts
Global Assessment of Trihalomethanes in Drinking Water
Impact Of Pollution on Asthma and Rhinitis
Exposome Project for Health and Occupational Research
Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors
Leveraging the European Genome-Phenome Archive (EGA) for Industry and Society
Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement
Cohorte Covid-19 en Cataluña
Signs of Early Adaptation to Climate Change
Exposure to emerging contaminants in drinking water in Barcelona potentially liked to chronic diseases and wellbeing
Las Voces de los Afectados por la Nefropatía Mesoamericana
Metabolomic Analysis as a Window into the Etiology of Mesoamerican Nephropathy
Co-created educational programme for dyspnea-bearing patients and their caregivers
Cohort of COVID-19 in Spain: social dynamics, mental health and inequalities
EXposome Powered tools for healthy living in urbAN SEttings
Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia
Alimentación S2: por una dieta saludable y sostenible
Estudio sobre la exposición a nano y microplásticos a través del agua de consumo de Barcelona
¿Es mejor consumir el agua de grifo si queremos reducir la exposición a nano/micropláticos?
Urban Health Citizen Lab
Characterizing Oral Exposure to Nanoplastics and Microplastics
Characterization of Oral NMP Exposure
In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform
An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)
Digital Twins Enabled Indoor Air Quality Management for Healthy Living
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
The Urban Burden of Disease Estimation for POLICY Making
Exposición prenatal a sustancias poli y perfluoradas en agua de consumo y neurodesarrollo en el inicio de la vida
Project Code: PI20/00829
Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease