AiguaBCN
Exposure to emerging contaminants in drinking water in Barcelona potentially liked to chronic diseases and wellbeing
- Duration
- 01/01/2020 - 30/06/2021
- Coordinator
- Cristina Villanueva Belmonte
- Funded by
- Ajuntament de Barcelona, "la Caixa" Foundation
Drinking water may contain emerging contaminants related to chronic diseases and ageing.
Objectives
Evaluate exposure to emerging pollutants in drinking water in Barcelona.
- Measure perfluorinated substances (PFASs), bisphenol A (BPA), nonylphenol (NP), haloacetic acids (HAAs), chlorite and chlorate in drinking water.
- Create a map of the concentrations in Barcelona;
- Estimate the contribution of drinking water on the internal dose of PFASs and trichloroacetic acid;
- Measure neurotoxicity in drinking water;
- Quantify the contribution of PFASs, BPA, NP, HAAs, chlorite and chlorate on the in vitro neurotoxicity.
Methods
Descriptive study in Barcelona. 42 points (one per zip code) will be defined to take a sample of tap water. 10 samples of bottled water will be included, selecting the most popular brands, and 10 samples of filtered tap water (5 from reverse osmosis and 5 from filter jar).
The concentration of PFASs, BPA, NP, HAAs, chlorite and chlorate will be measured using sensitive methods based on chromatography and mass spectrometry.
Urine samples will be taken in 42 volunteers living in the homes sampled to measure PFASs and trichloroacetic acid, and the relative contribution of drinking water to urine levels will be estimated.
A generalized additive model will be applied to predict the level of PFASs, BPA, NP, HAAs, chlorite and chlorate at all points in Barcelona based on the levels measured.
In a subsample (N = 30) in vitro tests will be applied to estimate neurotoxicity in water samples using human neuroblastoma SH-SY5Y cells. The contribution of the different chemicals analyzed on each of the responses in vitro will be estimated using regression models.
AiguaBCN is a collaborative project led from ISGlobal in collaboration with IDAEA-CSIC (Dra. Cintia Flores, Dr. Josep Caixach, Dra. Marinella Farré), URV-Tecnatox (Dra. Marta Schuhmacher, Dr. Joaquim Rovira), ICRA (Dr. Maria José Farré), and UFZ (Dr. Beate Escher).
Impact
First complete information on exposure to emerging compounds in drinking water in Barcelona, with the potential to assess effects related to ageing in the population.
Total Funding
149.996,49 €
How to participate
Our Team
Coordinator
- Cristina Villanueva Associate Research Professor
ISGlobal Team
- José Antonio Alcolea Statistician
- Lourdes Arjona Research Technician
- Maria Isabel Casas Sanahuja
- Paula Redondo Técnica de investigación
Other projects
See Past ProjectsMCC-Spain
Population based multicasecontrol study on common tumours in Spain
INMA - Environment and Childhood Project
ALEC (Aging Lungs in European Cohorts)
Ageing Lungs in European Cohorts
PROactive
Physical Activity as a Crucial Patient Reported Outcome in COPD
QUALI-VERD
OMEGA-NET
Network on the Coordination and Harmonisation of European Occupational Cohorts
Global Assessment of Trihalomethanes in Drinking Water
POLLAR
Impact Of Pollution on Asthma and Rhinitis
HERA
Integrating Environment and Health Research: a Vision for the EU
CORSAIR
Severe respiratory failure in COVID-19: clinical, biological and imaging risk factors
VEIS
Leveraging the European Genome-Phenome Archive (EGA) for Industry and Society
Mobilise-D
Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement
COVICAT
Cohorte Covid-19 en Cataluña
EARLY-ADAPT
Signs of Early Adaptation to Climate Change
Fotovoz
Las Voces de los Afectados por la Nefropatía Mesoamericana
Metabolomic Analysis as a Window into the Etiology of Mesoamerican Nephropathy
CALMA
Co-created educational programme for dyspnea-bearing patients and their caregivers
Cancer-Watch
Risk of colorectal and breast cancer with widespread drinking water chemical contaminants