Maternal, Child and Reproductive Health

PERS (bordetella PErtussis and Respiratory Syncytiual virus in pregnant women and their infants)

Contributing to the road map of maternal immunization: Determining the burden of Bordetella pertussis, respiratory syncytial virus (RSV) and Influenza virus in pregnant women and their infants in Mozambique

Duration
03/2017 - 03/2018
Coordinator
Azucena Bardají
Funded by
MINECO / Women in Science-UNESCO. L'Oreal Foundation

Maternal immunization represents a unique opportunity to protect pregnant women and their babies from diseases that cause substantial morbidity and mortality. Currently inactivated influenza, tetanus toxoid and acellular pertussis vaccines are recommended during pregnancy. Tetanus toxoid is the only widely implemented in low-income countries. Other vaccines under evaluation or in development for potential maternal immunization include group B Streptococcus, and respiratory syncytial virus (RSV). Acute respiratory infections such as those associated to Bordetella pertussis and RSV are among the most important causes responsible for morbidity and mortality during the first months of life. Pertussis is a highly infectious and severe respiratory disease than can be fatal in young infants, and currently and emergent global health problem.

This study aims to understand the burden and epidemiology of Bordetella pertussis, RSV and Influeza virus in pregnant women and young infants from Mozambique as site preparation investment for the evaluation of new vaccines during pregnancy to protect mothers, infants or both. The will be an observational, prospective study that will be conducted by the Manhiça Health Research Centre (CISM) and ISGlobal at the Manhiça District Hospital over 12 months, and that will enroll 250 pregnant women and their infants. The prevalence of infection by Bordetella pertussis, VRS and influenza virus will be determinated in pregnant women at the time of delivery, as well as in their infants after birth. The incidence of acute respiratory infections due to pertussis, VRS and influenza virus over the first 90 days of life will be determined among infants born to study women. The role of HIV and malaria in modifying the burden of pertussis, RSV and influenza virus will be also investigated. 

 

Our Team

PI

ISGlobal team

  • Clara Menéndez
    Clara Menéndez Research Professor, Director of the Maternal, Child and Reproductive Health Initiative and Programme
  • Elena Marban Castro
    Elena Marban Castro

Other projects

See Past Projects

COMBACTE

Combating Bacterial Resistance In Europe

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.

CaDMIA-plus

Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death

METRO

Measuring community prevalence among HIV exposed children in rural Southern Mozambique

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

www.mamahproject.net

ICARIA

Improving Care through Azithromycin Research for Infants in Africa