- 03/2017 - 03/2018
- Azucena Bardají
- Funded by
- MINECO / Women in Science-UNESCO. L'Oreal Foundation
Maternal immunization represents a unique opportunity to protect pregnant women and their babies from diseases that cause substantial morbidity and mortality. Currently inactivated influenza, tetanus toxoid and acellular pertussis vaccines are recommended during pregnancy. Tetanus toxoid is the only widely implemented in low-income countries. Other vaccines under evaluation or in development for potential maternal immunization include group B Streptococcus, and respiratory syncytial virus (RSV). Acute respiratory infections such as those associated to Bordetella pertussis and RSV are among the most important causes responsible for morbidity and mortality during the first months of life. Pertussis is a highly infectious and severe respiratory disease than can be fatal in young infants, and currently and emergent global health problem.
This study aims to understand the burden and epidemiology of Bordetella pertussis, RSV and Influeza virus in pregnant women and young infants from Mozambique as site preparation investment for the evaluation of new vaccines during pregnancy to protect mothers, infants or both. The will be an observational, prospective study that will be conducted by the Manhiça Health Research Centre (CISM) and ISGlobal at the Manhiça District Hospital over 12 months, and that will enroll 250 pregnant women and their infants. The prevalence of infection by Bordetella pertussis, VRS and influenza virus will be determinated in pregnant women at the time of delivery, as well as in their infants after birth. The incidence of acute respiratory infections due to pertussis, VRS and influenza virus over the first 90 days of life will be determined among infants born to study women. The role of HIV and malaria in modifying the burden of pertussis, RSV and influenza virus will be also investigated.
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Application to medical deviceshttp://www.nomorfilm.eu
Combatting Bacterial Resistance in Europe - Carbapenem Resistancehttps://www.imi.europa.eu/content/combacte-care
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individualshttps://clinicaltrials.gov/ct2/show/NCT02980016
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Development of New Metalloantibiotics Against Pathogens Associated to Chronic Infections in Cystic Fibrosis Patients
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africahttp://inteafrica.org/
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Continued validation of the minimally invasive autopsy for the investigation of the causes of death in infants, and establishment of a research and training center to study causes of death
Transforming IPT for optimal pregnancyhttps://www.tiptopmalaria.org
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Infección por virus Zika en mujeres embarazadas que han viajado a zonas afectadas y evaluación de impacto en salud infantil
An efficacy trial of the incremental mortality benefit of IPTi plus azithromycin