- June 2017 - September 2019
- Alberto García-Basteiro
- Funded by
- USAID / KNCV
This study is a parallel, two part, open label, individually randomized, pragmatic clinical trial to assess different alternatives to prevent tuberculosis (TB) among HIV-positive individuals. Part A compares a single round of weekly high dose rifapentine plus isoniazid for three months (3HP) to six months of daily isoniazid (6H). Part B compares periodic 3HP (p3HP) to a single round of 3HP.
This clinical trial aims to improve (shorten and simplify) currently available tools to prevent tuberculosis among HIV-positive individuals. The current recommendation is to provide single dose isoniazid daily during 6 months among HIV-positive individuals in whom TB disease has been ruled out. However, the implementation of this recommendation is limited in high burden countries, mostly due to adherence hurdles derived from such lengthy prophylaxis.
The study aims to enroll 4000 participants from three different countries: South Africa, Mozambique and Ethiopia. In Mozambique, the only participating site will be the Centro de Investigação em Saude de Manhiça (CISM).
1.6 million Euros
- Alberto García-Basteiro Assistant Research Professor
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Application to medical devices
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africa
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo
Pilot Study to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission
Cendea de Cizur
Conèixer la propagació. Entendre la protecció
A breakthrough device for the rapid detection of antimicrobial resistance
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Hepatitis B Virus COMmunity Screening and Vaccination in Africans
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
Close the Gap, Increase Access, Provide Adequate Therapy
Linkage and retention in care following home-based HIV testing serosurveys in Manhiça District, Southern Mozambique
Measuring community prevalence among HIV exposed children in rural Southern Mozambique
Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women
Predicting the Future: Incipient Tuberculosis
2nd Generation Color Agar Plates to Diagnose MDR-Tuberculosis: a Prospective Pilot Study