Asset Publisher

Chagas

TcONTROL

Antigen-specific immunological biomarkers associated to control of infection by T. cruzi.

Duration
01/01/2017-31/15/2019
Coordinator
Manuel Carlos López (IPBLN)
Funded by
MINECO

Los objetivos principales son:

  • Determinar en pacientes crónicos de Chagas el impacto del tratamiento con benznidazol en el perfil inmunológico (fenotípico y funcional) de las poblaciones linfocitarias T. El estudio se centrará en aquellos marcadores que se encuentren modificados según el grado de severidad de la patología de Chagas.
  • Caracterizar en un modelo de infección natural las modificaciones inducidas por el embarazo en el perfil inmunológico de linfocitos T CD4+ y CD8+, a nivel funcional y de expresión de receptores inhibitorios.
  • Analizar, utilizando un modelo murino de infección experimental, la respuesta inmunológica de células T  (CD4 y CD8)  potencialmente asociada al control de la infección por T. cruzi.

 

Financiación total:

121.000 €

Our Team

ISGlobal team

  • Joaquim Gascon Brustenga
    Joaquim Gascon Brustenga
  • Maria Jesús Pinazo Delgado
    Maria Jesús Pinazo Delgado

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