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Research, Malaria Elimination

Métodos para estimar la duración de la protección conferida por herramientas de prevención de la malaria

Project Code: PI12/02419

Duration: 01/01/2013 - 31/12/2016
Coordinator: John Jairo Aponte Varon
Funded by: Instituto de Salud Carlos III y Unión Europea. Cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

Tanto las vacunas, que afectan directamente el sistema inmune, como los fármacos antimaláricos, que afectan indirectamente el sistema inmune al modificar la exposición, pueden tener efectos de protección que duran mucho mas que lo que puede ser predicho por los parámetros farmacológicos clásicos como la biodisponibilidad o la vida media.

Diferentes factores afectan la estimación de la perdida de la eficacia y la duración de la misma, como la heterogeneidad de la exposición y de el efecto sobre los individuos, la estacionalidad o la inter-dependencia de los eventos en el análisis de múltiples episodios en un mismo sujeto.

No existe un consenso de cómo estimar la duración de la eficacia y el objetivo de este proyecto es desarrollar y evaluar nuevos métodos estadísticos para la estimación de la duración de la protección conferida por herramientas de prevención de malaria que se puedan utilizar en el análisis de ensayos clínicos.

Financiación

12.500 €

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Financiación

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