GlycoPar
Parasite glycobiology and anti-parasitic strategies

- Duration
- 01/11/20130 - 031/10/2017
- Coordinator
- Co-PI: Luis Izquierdo (with 12 partners)
- Funded by
- European Union – 7th FP – Marie Curie Innovative Training Network
- Website
- http://www.glycopar.eu/
Protozoan parasites and helminths are the cause of some of the most devastating diseases worldwide and a major effort is needed to be able to control or eliminate these diseases. Glycoconjugates are abundant and ubiquitous on the surface of many parasites and they are frequently involved in their survival strategies by forming a protective barrier against host defences. A common feature of the parasite’s cell surface architecture is the presence of an elaborate and often highly decorated glycocalyx that allows it to interact and respond to the external environment. Therefore, the study of the glycobiology of these organisms offers unique opportunities to devise novel strategies to tackle parasitic-caused diseases.
However, the exquisite diversity of these glycoconjugates and of their biosynthetic machineries, the difficulties related with their structural analysis and the complexity associated with their synthesis in the laboratory, poses a tremendous challenge for the scientific community.
To address these challenges GlycoPar network proposes to establish a European based training programme in a worldclass collaborative research environment steered by some of the world leaders in the fast evolving field of parasite glycobiology, in close association with European industrial enterprises.
The researchers recruited through this initiative will be exposed, both at the local and network-wide level, to a multicultural and highly multidisciplinary PhD training. This programme will acquaint them with a complete range of state-of-the-art glycobiology methodologies, alongside with valuable transferable and entrepreneurial skills. All together the aim is to create a PhD-level trained generation of young scientists capable of tackling the challenges that parasite glycobiology implies with improved career prospects and employability as well as preparing them to become future leaders in research institutions and industry.
Total funding:
3,450,856 € (ISGlobal 264,614 €)
Other projects
See Past ProjectsMESA
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.
RTS,S Vaccine Immunology Study
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial
Mozambican Alliance Towards Elimination of Malaria (MALTEM)
Mozambican Alliance Towards Elimination of Malaria
MiPMon
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
Severe malaria and microRNAs
A path towards new diagnostic and prevention tools for severe infectious pathologies
AlphaGal
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Epigenetic variation in malaria parasites II
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of P. vivax
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasite
TIPTOP
Transforming IPT for optimal pregnancy
BOHEMIA
Broad One Health Endectocide-based Malaria Intervention in Africa
ASINTMAL
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults
GenMoz
P. falciparum genomic intelligence in Mozambique
ADAM
Malaria mass and focal drug administration to advance malaria elimination in Mozambique: accelerating programmatic implementation and policy translation
MULTIPLY
MULTIple doses of IPTi Proposal: a Lifesaving high Yield intervention
ECO
Enhanced and equitable coverage of COVID-19 testing and treatment in Bolivia and Paraguay
Science4Pandemics
Citizens engagement digital platform for collective intelligence in pandemics
HIDDENVIVAX
Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria
Subclinical Infections in Children and Long Term Health Effects
Infection acquisition in early life and health outcomes in childhood - MARATO TV3
Diagnosis and Surveillance of Vector-Borne Viruses and Hemoparasites accross the Human Wildlife Interface in the Amazon Basin
Project Code: AC18/00054
Impacto de las coinfecciones en el balance de respuestas de anticuerpos y linfocitos T helper a antígenos diana de inmunidad natural y vacunal frente a patógenos humanos prominentes
Project Code: PI20/00866