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Exosomes for neglected diseases

Exosomes: new intercellular communicators and their applicability as therapeutic agents in neglected parasitic diseases

Duration: 07/04/2015-06/04/2018
Coordinator: Hernando A. del Portillo
Funded by: Fundació Ramón Areces

Parasitic diseases have affected humans since their emergence on Earth. These include diseases related to poverty such as malaria caused by Plasmodium vivax, Chagas disease caused by Trypanosoma cruzi and fascioliasis caused by F. hepatica.

We hypothesize that exosomes derived from these three human infections act in inter-cellular communication facilitating the establishment of infections. Moreover, the parasite-specific proteins associated with these exosomes will permit the identification of new antigens for vaccination, and the use of human reticulocyte-derived exosomes will serve as a new vehicle for antigen delivery and presentation to develop vaccines against these neglected tropical diseases.

This is a joint-project with Drs. Antonio Osuna (U. de Granada) and Antonio Marcilla (U. de Valencia) funded through the Fundación Ramón Areces.

Total funding

122,688.86 €

Principal Investigator

Hernando Del Portillo Obando

ISGlobal Team

Maria Carmen Fernandez Becerra
Joan Seguí
Marc Nicolau Fernández Lab Technician

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Total funding

Our Team

Principal Investigator

ISGlobal Team

Other projects

See all related projects

Cookies and privacy

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Changes to the Cookies Policy

Contact