- 01/01/2017 - 30/12/2019
- Funded by
- Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Juan Carlos III. Unión Europea. Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”
Airways infection remains the leading cause of morbidity and mortality, estimated at 85% in patients with cystic fibrosis (CF). Methicillin Resistant Staphylococcus aureus (MRSA), Haemophilus influenzae, Pseudomonas aeruginosa, Burkholderia cepacia complex, Stenotrophomonas maltophilia and no-tuberculosi mycobacteriae are the main microorganisms involved in these infections. Respiratory microbiota of a CF patient is exposed to a strong antibiotic pressure due to frequent and prolonged treatments, leading to the emergence of antimicrobial resistance and the selection of highly resistant strains.
The main objective of this project is the research and development of functional gold complexes (metalantibiotics) that are active against these microorganisms both in planktonic state as growing in biofilms. To do this, phenotypic methods directed to microbiological analysis of antomicrobial resistance (antibiogram), the analysis of resistance of biofilms (antibiofilmogram), the study of susceptibility against combinations of metalantibiotcs/conventional antibiotics, chemical methods for metalantibiotcs synthesis and development, as well as molecular methods such as genomics, will be used.
- Sara Soto Associate Research Professor and Head of the Viral and Bacterial Infections Programme at ISGlobal.
Other projectsSee Past Projects
Combating Bacterial Resistance In Europe
Application to medical devices
Combatting Bacterial Resistance in Europe - Carbapenem Resistance
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africa
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.
Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo
Pilot Study to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission
Cendea de Cizur
Conèixer la propagació. Entendre la protecció
A breakthrough device for the rapid detection of antimicrobial resistance
Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19
Hepatitis B Virus COMmunity Screening and Vaccination in Africans
Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV
Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.
Close the Gap, Increase Access, Provide Adequate Therapy
Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19
Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia
Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status
Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring
ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)