Publicador de contenidos

Streptococcus agalactiae

Caractericación molecular de su virulencia y resistencia y su aplicación al diagnóstico precoz de la infección perinatal

Duración
2014 - 2017
Coordinador
Sara Soto
Financiadores
Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

Neonatal sepsis is a major but undervaluated problem worldwide.

Streptococcus agalactiae is the microorganism most frequently associated with neonatal sepsis in developed and low income countries. In countries which have implemented preventive measures against the SGB, recommended by the CDC, cases of neonatal sepsis caused by this organism have decreased but the late neonatal sepsis cases still in their levels.

The project's objectives are to study the epidemiology, levels of antimicrobial resistance and the presence of virulence factors in strains; identify bacterial factors related to vertical transmission of bacteria from mother to child, and determine the relationship between time colonization, presence and levels of antibodies and risk of late neonatal sepsis.

To accomplish these objectives phenotypic (antibiogram, translocation) and genotypic techniques (PCR, cloning, mutagenesis, secretome) will be used that allow us to further characterize this organism and determine the basis for its transmisison vertically.

The data will be important in the detection, prevention, treatment and vaccination against this microorganism.

Project Code

PI13/00127

Nuestro equipo

Equipo ISGlobal

  • Sara Soto González
    Sara Soto González Associate Research Professor y directora del Programa de Infecciones Víricas y Bacterianas

Otros proyectos

Ver proyectos pasados

COMBACTE

Combatiendo la Resistencia Bacteriana en Europa

GAMA

Development of Novel Gastrointestinal Biomarkers for Use in HIV Incidence Determination in a Sub-Saharan African Setting

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

MAMAH

Improving Maternal and Infant Health by reducing malaria risks in African women: evaluation of the safety and efficacy of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in HIV-infected pregnant women

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

ICARIA

Improving Care through Azithromycin Research for Infants in Africa

PreFIT

Predicting the Future: Incipient Tuberculosis

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

ENDÈMIC

Community knowledge generation through scientific culture, urban ecology and art

EpiGen

Building Scalable Pathogen Genomic Epidemiology in Ethiopia

Hepatitis C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

FLAVOBAC

Nuevas moléculas de oro coordinadas con flavonoides contra bacterias patógenas multirresistentes prioritarias