Streptococcus agalactiae

Caractericación molecular de su virulencia y resistencia y su aplicación al diagnóstico precoz de la infección perinatal

Duración
2014 - 2017
Coordinador
Sara Soto
Financiadores
Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”

Neonatal sepsis is a major but undervaluated problem worldwide.

Streptococcus agalactiae is the microorganism most frequently associated with neonatal sepsis in developed and low income countries. In countries which have implemented preventive measures against the SGB, recommended by the CDC, cases of neonatal sepsis caused by this organism have decreased but the late neonatal sepsis cases still in their levels.

The project's objectives are to study the epidemiology, levels of antimicrobial resistance and the presence of virulence factors in strains; identify bacterial factors related to vertical transmission of bacteria from mother to child, and determine the relationship between time colonization, presence and levels of antibodies and risk of late neonatal sepsis.

To accomplish these objectives phenotypic (antibiogram, translocation) and genotypic techniques (PCR, cloning, mutagenesis, secretome) will be used that allow us to further characterize this organism and determine the basis for its transmisison vertically.

The data will be important in the detection, prevention, treatment and vaccination against this microorganism.

Project Code

PI13/00127

Nuestro equipo

Equipo ISGlobal

Otros proyectos

Ver proyectos pasados

COMBACTE

Combatiendo la Resistencia Bacteriana en Europa

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.