- 2014 - 2017
- Sara Soto
- Ministerio de Ciencia, Innovación y Universidades. Instituto de Salud Carlos III Unión Europea Este proyecto está cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). “Una manera de hacer Europa”
Neonatal sepsis is a major but undervaluated problem worldwide.
Streptococcus agalactiae is the microorganism most frequently associated with neonatal sepsis in developed and low income countries. In countries which have implemented preventive measures against the SGB, recommended by the CDC, cases of neonatal sepsis caused by this organism have decreased but the late neonatal sepsis cases still in their levels.
The project's objectives are to study the epidemiology, levels of antimicrobial resistance and the presence of virulence factors in strains; identify bacterial factors related to vertical transmission of bacteria from mother to child, and determine the relationship between time colonization, presence and levels of antibodies and risk of late neonatal sepsis.
To accomplish these objectives phenotypic (antibiogram, translocation) and genotypic techniques (PCR, cloning, mutagenesis, secretome) will be used that allow us to further characterize this organism and determine the basis for its transmisison vertically.
The data will be important in the detection, prevention, treatment and vaccination against this microorganism.
- Sara Soto Associate Research Professor
Otros proyectosVer proyectos pasados
Combatiendo la Resistencia Bacteriana en Europa
Erradicación del Pianhttp://pian.isglobal.org
Application to medical deviceswww.nomorfilm.eu
Combatting Bacterial Resistance in Europe - Carbapenem Resistancehttps://www.imi.europa.eu/content/combacte-care
Prioritising Antimicrobial Resistance: establishing an interdisciplinary International Research Partnership to tackle an evolving global health threat
An interdisciplinary International Research Partnership to tackle an evolving global health threat
Development of new metal-antibiotics against pathogens causing chronic infections in patients with cystic fibrosis.
New metal-antibiotics for patients with cystic fibrosis
Non-invasive ultrasound-based screening for meningitis: Proof-of concept in infants
Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique
Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individualshttps://clinicaltrials.gov/ct2/show/NCT02980016
Search for new target proteins and use of antibacterial or inhibitory peptides against resistance mechanisms in 'Acinetobacter baumannii'
Desarrollo de nuevos metaloantibióticos frente a patógenos causantes de infecciones crónicas en pacientes con fibrosis quística
Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique
Integrating and decentralizing diabetes and hypertension services in Africahttp://inteafrica.org/
Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.