- 01/03/2018 - 28/02/2021
- Xavier Fernàndez-Busquets
- Funded by
- ERA-NET Cofund EURONANOMED III.
Whereas nanomedical approaches to cure diseases are prevalent in the developed world, there is an astonishing lack of nanomedicines to treat the main causes of death in the impoverished areas of the planet: infectious diseases, among which malaria is prominent.
The unmet medical and patient need of malaria eradication will not be achieved unless the targeted delivery of new drugs is vastly improved. Encapsulation of drugs in targeted nanovectors is a rapidly growing area with a clear applicability to infectious disease treatment, and pharmaceutical nanotechnology has been identified as a potentially essential tool in the future fight against malaria. Polymers offer virtually unlimited diversity in chemistry, dimensions and topology, which renders them a class of materials that is particularly suitable for applications in nanoscale drug delivery strategies.
The objective of NANOpheles is to design polymeric nanovectors for the delivery of antimalarial agents to Plasmodium stages in the mosquito, and to characterise the efficacy of nanovectors and antimalarial agents to reduce mosquito infectiousness.
This objective will be achieved through:
- synthesis of nanocarriers capable of encapsulating antimalarials (currently used drugs and future antimicrobial peptides, antibodies, and dsRNA) and of preventing their degradation in storage conditions
- engineering of targeted nanovectors capable of delivering their antimalarial contents to Plasmodium stages in the Anopheles mosquito
- evaluation of the effect of selected nanovectors (loaded with antimalarial agents) on the mosquito stages of Plasmodium and their transmission capacity in a murine model of malaria
NANOpheles unites groups which are leading laboratories in nanoparticle synthesis, targeted drug delivery to Plasmodium-infected cells, molecular and cell biology of malaria, mouse models and mosquito vectors of malaria, and clinical aspects of malaria.
ERA-NET Cofund EURONANOMED III. EUROPEAN INNOVATIVE RESEARCH & TECHNOLOGICAL DEVELOPMENT PROJECTS IN NANOMEDICINE
Other projectsSee Past Projects
The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication.http://www.malariaeradication.org/
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trialhttp://www.sysmalvac.eu/
Mozambican Alliance Towards Elimination of Malaria
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
A path towards new diagnostic and prevention tools for severe infectious pathologies
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasitehttp://www.pvrex.com/
Transforming IPT for optimal pregnancyhttps://www.tiptopmalaria.org
Broad One Health Endectocide-based Malaria Intervention in Africahttp://bohemiaconsortium.org
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults