- Feb 2019 - Feb 2024
- Regina Rabinovich
- Funded by
The world is not on track to achieve the goals proposed by WHO in the Global Technical Strategy for Malaria 2016-2030 (GTS), and currently available tools are unlikely to suffice. Vector control, our most effective strategy, is now doubly threatened by widespread insecticide resistance and residual transmission caused by mosquito behavioral adaptations that allow them to elude home-based vector control tools such as treated bed nets and indoor residual spraying.
Ivermectin is an antiparasitic drug distributed to more than 2.5 billion people over the last 30 years in mass drug administration campaigns to directly treat two Neglected Tropical Diseases (NTDs). More recently, it has been noted that ivermectin can also increase the mortality of mosquitoes that feed on treated humans or animals during a time period that can be up to 28 days, depending on the dose.
Thus, Mass Drug Administration (MDA) of ivermectin to humans and/or livestock holds potential to complement the malaria toolbox by tackling residual transmission and help the malaria community get back on track to achieve the GTS goals.
BOHEMIA will evaluate the MDA of ivermectin to humans and/or livestock in two African countries - Mozambique and Kenya - during the malaria season, and will collect data on the epidemiological impact to support normative guidance, global and national policy change.
Should evidence be supportive, engagement with WHO and other key stakeholders will support the conditions for a policy recommendation, and subsequent national adoption.
BOHEMIA combines evidence generation and stakeholder engagement to enable the path for policy and implementation of ivermectin as a new vector control tool complementary to standard tools (treated bed nets and indoor residual spraying).
The BOHEMIAconsortium is led by ISGlobal and includes:
- Centro de Investigaçao em Saúde de Manhiça
- Ifakara Health Institute
- University Hospital Bern
- University of Oxford
- Virginia Tech
The MDA is being implemented in Mozambique by the Centro de Investigação em Saúde de Manhiça (CISM), and in Kenya by the Kenya Medical Research Institute in collaboration with the KEMRI | Wellcome Trust research program.
25.3 U$ million (awarded by Unitaid)
Regina Rabinovich Director of the Malaria Elimination Initiative
CARLOS CHACCOUR Assistant Research Professor. BOHEMIA Co-PI and Chief Scientific Officer
Paula Ruiz-Castillo Postdoctoral Fellow
Patricia Nicolás Predoctoral Fellow
Mary Mael Project Manager
Beatriz Fiestas Communications Coordinator. Campus Clínic
Sònia Tomàs Project Manager, BOHEMIA Outreach Coordinator
Vincent Bouvaist Financial Manager
Caroline Kiuru Entomologist
Júlia Montañà Predoctoral Researcher
Almudena Sanz Project Technician
Marta Ribes Predoctoral Researcher
Joanna Furnival Adams Predoctoral Researcher
Murchana Roychoudhury Communications Officer
Sara Stanulovic Project Assistant
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