Publicador de continguts

Recerca, Eliminació de la malària

HIDDENVIVAX

Novel organ-on-a-chip technology to study extracellular vesicles-mediated cryptic infections in Plasmodium vivax malaria

Durada
October 1st 2021 - October 1st 2024
Coordinador
Hernando A. del Portillo Obando
Finançadors
“la Caixa” Foundation

Infectious diseases, many of them forgotten, kill 17 million people every year in the poorest regions on the planet. One such disease is malaria caused by the world’s most widely distributed malaria parasite, Plasmodium vivax.

One of the many unanswered questions is the origin of asymptomatic chronic infections with numerous epidemiological field studies supporting >90% of such infections. One hypothesis is that nanovesicles called exosomes, mediate cryptic infections in the human bone marrow and spleen, with clear implications for malaria elimination.

This project aims to develop a miniature model of human bone marrow and spleen (organ-on-a-chip technology) to investigate the parasite’s hiding places in the organism, uncover the role of the exosomes and eliminate malaria.

 

Total Funding

996,930.57 euro

Our Team

Coordinator

ISGlobal Team

Altres projectes

R21 AI151459-01A1

Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi

BASEMALVAC

Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regions

GlycoTargets

Noves teràpies antimalàriques dirigides contra les vies de glicosilació de 'Plasmodium falciparum'

CLIMSOCTRYPBOL

Insight on climate and social participatory research for integral management of vectorborne zoonosis caused by Trypanosoma cruzi and Leishmania spp. in the Bolivian Gran Chaco.

VaMonoS

Unravelling the heterogoneity and function of monocytes in vaccination and immunity to malaria

VivaxEVTalk

Extracellular Vesicles as Intercellular Communicators and Biomarkers of Cryptic Erythrocytic Infections in Plasmodium vivax malaria

RESPONSE

Mechanisms of the transcriptional responses to changes in the environment in the malaria parasite Plasmodium falciparum

MalTransc

Transcriptional regulation of adaptation and developmental decisions in malaria parasites: from epigenetic variation to directed transcriptional responses