Melisa Gualdrón-López is a molecular parasitologist interested in Neglected Tropical Diseases. During her career she has specialized in the study of Trypanosomatid parasites: Leishmania mexicana (parasite responsible for cutaneous Leishmaniasis in the New World), Trypanosoma brucei, the etiologic agent of human Sleeping Sickness in Africa and Trypanosoma cruzi, the parasite that causes Chagas Disease.
Her research has focus in understanding the parasites energy metabolism, more precisely the function and biogenesis of glycosomes, peroxisome-like organelles where glycolysis is compartmentalized, with the objective of identifying quimioterapeutic targets.
She is also interested in host-parasite interactions and in immune response mechanisms that fight parasitic infections. In 2016, she joined Dr. Hernando A del Portillo and Carmen Fernandez-Becerra laboratory at the Barcelona Institute for Global Health and the Institute for Health Science Research Germans Trias i Pujol (IGTP) to study extracellular vesicles derived from Plasmodium vivax infections aiming of identify potential antigens for vaccine development and biomarkers of disease.
Líneas de investigación
- Biomarkers discovery of Plasmodium vivax hypnozoites associated to extracellular vesicles.
- Role of the extracellular vesicles in spleen patophysiology and cytoadherance in Vivax malaria
- Plasmodium vivax antigen discovery associated to extracellular vesicles
- Toda H et al. Nat. Comm.11, (2020)
- Gualdrón-lópez, M. et al., Front. Microbiol. 9, 1–15 (2018)
- Brant, F. et al. Brain. Behav. Immun. 54, (2016)
- Barroso, A. et al. Infect. Immun. 84, (2016)
- Gualdrón-López, M. et al. Biochim. Biophys. Acta - Mol. Cell Res. 1833, (2013).