Research

SToolNIH

Quantifiable stool-based TB PCR to Improve Diagnostics and Treatment Monitoring

Unidad de desnutrición infantil en la planta de Pediatría del Hospital de Manhiça
Duration
01/09/2020 - 01/09/2024
Coordinator
Anna Maria Mandalakas / Alberto García-Basteiro
Funded by
National Institutes of Health (NIH)

This project aims to validate an innovative stool homogenization and DNA isolation method that yields a highly sensitive and specific Mtb qPCR-based diagnostic. StoolTB will evaluate this platform in the high TB and HIV burden settings of Mozambique, eSwatini and Uganda under the hypothesis that it will narrow the large TB case detection gap by improving TB confirmation rates in children and people living with HIV while proving feasible and acceptable.

Total Funding

$ 2,475,880.00

Our Team

Coordinators

  • Alberto García Basteiro
    Alberto García Basteiro
  • Anna Maria Mandalakas
    Anna Maria Mandalakas

ISGlobal Team

Other projects

See Past Projects

COMBACTE

Combating Bacterial Resistance In Europe

COMBACTE-CARE

Combatting Bacterial Resistance in Europe - Carbapenem Resistance

Xpatial-TB

Improved case detection through TB contact risk stratification by Xpert results and spatial parameters in Mozambique

WHIP3TB

Evaluation of the effect of weekly high dose rifapentine and isoniazid (3HP) vs periodic 3HP vs 6H for preventing TB among HIV-positive individuals

VINCI

Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique

INTE-AFRICA

Integrating and decentralizing diabetes and hypertension services in Africa

AVATAR

Searching the hidden: evaluating dengue, chikungunya and Zika autochthonous transmission in the city of Barcelona.

COVID-PREG

Eficacia de hidroxicloroquina en la prevención de la infección por SARS-CoV-2 y de la gravedad de la enfermedad de COVID-19 durante el embarazo

AMR DetecTool

A breakthrough device for the rapid detection of antimicrobial resistance

ANTICOV

Large Clinical Trial in Africa on the Treatment of Mild Cases of COVID-19

HBV-COMSAVA

Hepatitis B Virus COMmunity Screening and Vaccination in Africans

Stool4TB

Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV

Hep C Free Baleares

Eliminating hepatitis C on the Balearic Islands (Mallorca, Menorca and Ibiza): a study in governmental and non-governmental addiction service centres, a mobile methadone unit and a prison to test and link people who use drugs to HCV care.

CAPTB

Close the Gap, Increase Access, Provide Adequate Therapy

STREESCO

Strengthening Epidemiological Surveillance in Benin and Burkina Faso for an Effective Response to COVID-19

COVAIR-CAT

Air Pollution in Relation to COVID-19 Morbidity and Mortality: A Large Population-Based Cohort Study in Catalonia

TB-RECONNECT

Reconnecting Transmission to Global Tuberculosis Control by Mapping Pathogen Transmission Events to Host Infection Status

END-VOC

ENDing COVID-19 Variants Of concern through Cohort studies (END-VOC)