The Malaria Eradication Scientific Alliance - MESA is dedicated to advancing the science of malaria eradication. Other disease eradication efforts, past and present, have taught us the critical role of research and development. The Malaria Eradication Research Agenda (malERA) laid the foundation for this R&D effort, which MESA builds upon.
MESA's objectives and activities are aligned with Roll Back Malaria's Global Malaria Action Plan strategy to research new tools and approaches to support global control and elimination efforts. With the community, MESA monitors progress and takes the next steps to advance the science of malaria eradication. MESA reviews existing evidence and supports projects on research questions critical to malaria eradication.
MESA fulfils four key functions:
1. Ideas incubator
Meaning ‘table', MESA provides the space for the multidisciplinary community to:
- Examine the state of the art in malaria eradication science.
- Showcase new evidence and emerging data at a scientific meeting dedicated to malaria eradication science, in collaboration with Keystone.
- Debate new challenges and generate new ideas.
- Conceptualise research activities including projects, studentships and evidence reviews.
2. Knowledge management
Vital questions for advancing the science of malaria eradication include "what do we know?" and "what don't we know?" MESA provides knowledge management processes to tackle these questions, through:
- Systematic review of existing information on the effectiveness of interventions and approaches for malaria elimination.
- Quality assessment of the evidence.
- Partnering with the WHO GMP to access information.
- Disseminating the findings and building the evidence base.
3. Catalysing research
MESA endorses and supports research testing novel ideas as well as research using existing tools differently, through:
- Support to projects through competitive grants.
- Endorsement of projects for other funding streams.
- Support to studentships through competitive awards.
4. Monitoring progress
MESA tracks progress and feeds back to the community, through:
- Tracking investment levels and trends in R&D driven by the eradication goal, in collaboration with Policy Cures.
- Updating the malaria eradication R&D agenda.
- Reporting on progress.
MESA functions are cyclical; examining evidence, identifying gaps and new priorities leading to new projects and the continual development of the malaria eradication research agenda.
The MESA Steering Committee, chaired by Pedro Alonso, governs MESA and the MESA Strategic Advisory Council provides overall guidance. The MESA Secretariat is hosted by ISGlobal (Barcelona Institute of Global Health), Kate Whitfield is the MESA Project Manager. For further information please contact the MESA Secretariat at firstname.lastname@example.org
MESA Research Portfolio
In 2012, MESA set up a process to identify and select research projects which advance the science of malaria eradication. Following a call for proposals in two thematic areas: 'Measurement of transmission' and 'Health systems' readiness', project proposals were appraised by independent peer review panels. Three projects in each theme were selected for financial support by MESA and one proposal was endorsed for support through other funding streams. Research activities in the six projects span Africa, Asia, Latin America and Australasia and are relevant to both P. falciparum and P. vivax malaria. See the process schematic and project summaries here .
- New tools for vector control and diagnosis
- Use of mapping technologies for surveillance and tailored response
- Mobile applications for populations living in areas with poor access
Malaria Policy Advisory Committee to the WHO
- recommendations for achieving universal coverage of long-lasting insecticide-treated nets
- guidance on estimating the longevity of insecticide-treated nets
- improving capacity in entomology and vector control
- a review of the latest evidence on intermittent preventive treatment in pregnancy
- updates on the development of the global technical strategy for malaria control and elimination (2016–2025) and the global strategy for control and elimination of Plasmodium vivax
- and much more.
Other projectsSee Past Projects
Study of immune correlates of protection against malaria after vaccination with RTS,S/AS01E: a comprehensive immunological arm of a Phase III double-blind, randomized, controlled multi-center trial
Mozambican Alliance Towards Elimination of Malaria
Pregnant women as a sentinel group for malaria surveillance in an era of changing malaria transmission
A path towards new diagnostic and prevention tools for severe infectious pathologies
Exploration of the singularities of the sugar nucleotide metabolism and description of novel glycosylation pathways in the malaria parasite
Investigating new aspects of the mechanisms and biological functions of epigenetic variation in malaria parasites
Mechanistic aspects of anemia and splenomegaly caused by plasmodium vivax, a neglected human parasite
Transforming IPT for optimal pregnancy
Development of nanovectors for the targeted delivery in Anopheles mosquitoes of agents blocking transmission of Plasmodium parasites
Broad One Health Endectocide-based Malaria Intervention in Africa
Unravelling Disease Tolerance and Host Resistance in Afebrile 'P. falciparum' Infections: a Prospective Study in Mozambican Adults