Publicador de contenidos

Investigación

HORMONIT

Molecular Epidemiological Study on Hormonal Changes Associated with Circadian Disruption in Night Shift Workers

Proyecto HORMONIT
Foto: Matthew Henry / Unsplash
Duración
2015-2019
Coordinador
Manolis Kogevinas
Financiadores
Instituto de Salud Carlos III - FEDER (PI14/00444)

Night shift work has been associated with cancer risk, but the biological mechanisms are not well established. The HORMONIT study will evaluate the effects of circadian disruption due to night shift work on the production and timing of sex steroid hormones, the production of cytokines, and the metabolomic profile of night shift workers.

Approximately 60 male, rotating shift workers will be included in the HORMONIT study, funded partially by the Instituto de Salud Carlos III-FEDER (PI14/00444). All participants will be sampled twice on two working days (one during their day shift rotation and another during their night shift rotation). During each of the two days of data collection, all urine voids will be collected for 24 h, continuous personal measurements of light will be made, multiple blood samples will be extracted, and participants will respond to a baseline and separate day shift and night shift questionnaires.

The study will provide evidence on molecular and hormonal mechanisms to explain the increase in cancer and other common non-communicable diseases among night shift workers. It will also allow us to establish recommendations on optimal patterns for workers based on experimental evidence.

Questionnaires

Publications

Nuestro equipo

Coordinator

ISGlobal Team

Otros proyectos

Ver proyectos pasados

MCC-Spain

Estudio multi-caso control poblacional, incluyendo tumores de alta incidencia en España

HELIX

Novel tools for integrating early-life environmental exposures and child health across Europe

EGG/EAGLE

Early Genetics Growth/Early Genetics and Lifecourse Epidemiology

PACE

Pregnancy and Childhood Epigenetics

LIFECYCLE

Early-life stressors and LifeCycle health

OMEGA-NET

Network on the Coordination and Harmonisation of European Occupational Cohorts

HARMONIC

Health effects of cArdiac fluoRoscopy and mOdern radIotherapy in paediatriCs

Mobilise-D

Connecting digital mobility assessment to clinical outcomes for regulatory and clinical endorsement

EARLY-ADAPT

Signs of Early Adaptation to Climate Change

COVICAT

Cohorte Covid-19 en Cataluña

ATHLETE

Advancing Tools for Human Early Lifecourse Exposome Research and Translation

CONTENT

Cohorte de COVID-19 en España: dinámica social, salud mental y desigualdades

EUCAN-Connect

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

OBERON

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

EXPANSE

EXposome Powered tools for healthy living in urbAN SEttings

AURORA 2021

Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

ONES

Fine Particle Matter, Fetal Growth, and Neurodevelopment: Examining Critical Windows of Susceptibility

AIR-NB

Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development

NutinBrain

The role of seafood and nut consumption on human neurodevelopment from pregnancy to adolescence

UrbanKids

Urban and social environment and childhood obesity – a natural moving2health experiment

iGenCO

In-Depth Genomics and Cross-Omics Analysis for Undiagnosed Rare Diseases on a User-Friendly Collaborative Platform

CityExposomeCat

An Exposome Approach to Urban Health: Individualized Environmental Exposure Assessment in an Adults Population Cohort Study (GCAT)

TwinAir

Digital Twins Enabled Indoor Air Quality Management for Healthy Living

UBDPOLICY

The Urban Burden of Disease Estimation for POLICY Making

TOLIFE

Combining Artificial Intelligence and smart sensing TOward better management and improved quality of LIFE in chronic obstructive pulmonary disease

BWater

Drinking Water in Barcelona: Sustainability and Health Impact Assessment

intoDBP

Innovative Tools to Control Organic Matter and Disinfection Byproducts in Drinking Water

FINDOOR

FTIR spectroscopy for real-time detection of bacterial outbreaks and the rapid identification of pathogenic serotypes, relapsing infections and antibiotic resistance

OccRF-Health

Occupational exposure to radiofrequency electromagnetic fields: From exposure assessment to study of health in workers and their offspring

EPHOR

Exposome Project for Health and Occupational Research

EXPONIT

Analysing and studying how night shift work affects workers' circadian rhythms and health

IHEN

International Human Exposome Network

B-Triage

Una prueba en el punto de atención para la estratificación del riesgo de los pacientes febriles basada en los niveles de sTREM-1

e-QuoL

e-health tools to promote Equality in Quality of Life for childhood to young adulthood cancer patients, survivors and their families

AM-MENTAL

¿Cómo afecta a tu salud mental que tu jefe o jefa sea un algoritmo?